Gastric carcinoma the intersection of chemotherapy and scheme and tactics develop _'s treatment

Gastric carcinoma the intersection of chemotherapy and scheme and tactics develop _'s treatment
Gastric carcinoma is one of the most common malignant tumour, its prognosis is relatively bad. It is still a main means to radically treat gastric carcinoma that the operation is totally excised. But the postoperative recuring rate of gastric carcinoma is up to 50%- 70%, 5 only 20%- 50% of survival rate, so people have been seeking to treat the method of gastric carcinoma in order to improve the prognosis of the gastric carcinoma patient beyond surgery. Since the sixties of the 20th century, chemotherapy has begun to be applied to gastric carcinoma, chemotherapy medicine and scheme " rose one after another " hereafter ,But the postoperative auxiliary chemotherapy of gastric carcinoma still can't be satisfactory so far. New medicine and treating the appearance of the tactics to make the application in gastric carcinoma of chemotherapy present the new opportunity newly.
Gradual progress of a gastric carcinoma chemotherapy
1.1 Early progress of chemotherapy of gastric carcinoma
Gastric carcinoma chemotherapy begin with will it be the sixties the 20th century, research of 5 Fu, most completely, but single the intersection of medicine and application effect unsatisfied with, always the reacting rate is up to 21% [1 ] at most. Unite chemotherapy, begin, appear the seventies, FAM (the intersection of Fluorine and the intersection of urea and pyrimidine, the intersection of A and mould plain, mitomycin C) among them It is comparatively extensive that the scheme is employed. But the random controlled study reveals FAM, FA (5 Fu, A are mould and plain) , the single medicine 5 Fu treats the response rate of gastric carcinoma with life cycle but there is no obvious difference [2 ]. Wils,etc. [3 ] find FAMTX (the intersection of Fluorine and the intersection of urea and pyrimidine, the intersection of A and mould plain, the intersection of ring and phosphorus amide) Response and it is middle superior to by FAM location life cycle. FAMTX has been regarded as the standard scheme of chemotherapy America and Europe for the moment.
Calcium tetrahydrofolic acid could strengthen the toxic function of cell of 5 Fu to get definitely in the eighties, make the reacting rate up to 33%- 44%, the chemotherapy scheme taking regulating the idea in biochemistry as foundation is studied to begin progressively. Obey the quotation of platinum and spirit mortar medicine, make a great deal of union chemotherapy schemes come out, such as FUP (Fluorine urea pyrimidine, obey platinum) , ELF (glucoside, inferior calcium folic acid, Fluorine urea pyrimidine of foot leaf second) When.
The 1990s PELF (infuse along mould plain, inferior calcium folic acid, Fluorine urea pyrimidine vein of platinum, table A) With ECF (table A is mould and plain, instils Fluorine urea pyrimidine continuously along platinum, vein) Rise for the chemotherapy scheme of the main fact. Compared with FAMTX, PELF can obviously increase the reacting rate, but there is no obvious extension to total life cycle. And ECF treat response rate of gastric carcinoma and middle location have, raise in life cycle, including 46% and 8.7 months [4 ]. Spanish intestines and stomach tumour treats the group (TTD) One of 2 stages clinical trial last medicine 5 Fu veins lastings heavy dose of to instil to can reach 18% to last gastric carcinoma reacting rate, add, use along platinum can make person who react up to 44%, employ table jointly and then A mould to increase the reacting rate while being plaining, but gastrointestinal tract and blood toxicity obviously increase.
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