The function _'s treatments of gastric carcinoma and lymphocytic factor of the immunity

The function _'s treatments of gastric carcinoma and lymphocytic factor of the immunity
T lymphocyte formate a lot of lymphocytic factors, and many other cell factors, some they relate to treatment of tumour, interferon, shift factor, leucocyte, lie between plain, etc, these lymphocytic factors, some can wound tumour cells, some can stimulate hematopoiesis to organize, oppose the side effect of chemotherapy or radiotherapy.
( 1) Interferon
Interferon divide three of , , , compound interferon, people of leucocyte, have certain results on making and organizing tumour
,To spend the medium-sized dosage ' 10* 106/m2) ,Every week 3, amount to 8 week, efficient to reach 44%~54%, can have validity for 16~55 week, have the same result on lymphoma leukemia with interferon of , there is certain curative effect to some entity tumours too, but it is that quantity should be improved to use unexpectedly.
Interferon of is a product of T lymphocytes, effective to hematopoietic tumour and entity tumour, some if maos of cell have the intersection of and the intersection of interferon and receptor, have interferon to receive the body, brief on failing to respond to any medical treatment to hair cell leukemia of interferon of .
Someone carries on the experiment with the stomach cancer cell SGC-7901, after interferon is dealt with, soaks the improvement to some extent of sensitiveness that lymphocytes wounded gastric carcinoma. If deal with the necrosis factor together with interferon SGC-7901 cells, it is more prominent to make gastric carcinoma soak lymphocytes and wound function, but interferon induces lymphocytes not to influence to IL-2.
Use interferon to watch out for its side effect. 's interferon consumption is over 360,000 units, will bring out the serious poisonous side effect, numerous people display the sexual desire and fail, the behavior changes.
( 2) Bai JieSu - 2
It is some materials which promote the lymphocyte function to lie between in vain plainly, IL-2 is that the growth of T cells is helpful, it can activate T lymphocytes, T lymphocytes have receptors of IL-2, therefore there is very great facilitation on cell immunity, employ in the independent body, IL-2 of the high dosage has certain antitumor results, animal's experiment proves, give, inoculate the intersection of A-105 and the intersection of liver and little the intersection of mouse and high the intersection of IL-25 and Wan of dosage sarcomatous, to 150,000, can make experimental the intersection of group and little tumour of mouse shift, lower by 66%~95% contrasting the little mouse, but does not use as the lymphocytes (LAK) training this animal on the body IL-2 for external use first alone ,Then pour into the body, can produce the prominent antitumor result by 20,000 to 25,000 units, Rosenberg means that summarized 652 results that tumour patient used IL-2LAK cells in later period in 1989, use IL-2 on indicating it is clinical at present that IL-2LAK cells are superior to using IL alone, is used mainly in the preparation of LAK cells, still need to be relatively heavy dose of while using, the side effect is great, stress that is shown as " the capillary leaks " ( Capillary leak) .
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