Gastric carcinoma solves _'s general knowledge newly

Gastric carcinoma solves _'s general knowledge newly
2/3 of the global gastric carcinoma take place in China, Japan and South Korea, annual death is more than 160,000 people, probably there is a Chinese every 2- 3 minute to die of gastric carcinoma. Pathological change was developed slowly before cancer of gastric carcinoma, even reversible one, but the early patient did not almost have any specific symptom. Pathological change before so if can monitor cancer in early days, perhaps can reduce the emergence of gastric carcinoma.





New explanation of gastric carcinoma



Digest and absorption is that the human body obtain the foundation that energy can survive, the stomach is acting among them very much

It is the important role, perhaps it is the diligent work of a stomach at all hours of the day and night, have neglected varied causing

Son's attack of it an open spear thrust and an arrow in the dark of the cause of disease. The forest forest of cause of disease of gastric carcinoma is always always, complicated and various, it defends

Manage, the difficulty is, early patients of most gastric carcinomas do not almost have any specific symptom,

Already been in later period when the patient went to a doctor. But pathological change is developed quite slow before cancer of gastric carcinoma at the same time,

Even reversible one, pathological change before if can monitor cancer in early days, perhaps can reduce the taking place of gastric carcinoma

Grow.

Entire PLA digest the intersection of disease and research institute, the intersection of PLA man and fourth army medical university the intersection of generation and bright, Zhang Xue mediocre professor Fan

When lead seminar, go through research for 25 year, explore suitable of our country gastric carcinoma of national conditions already at present

Research approaches serial,since cancer that is dangerous most pathological change to serology diagnose, and many medicines are able to bear medicines

Relevant molecule clones and such respects as gastric carcinoma vaccine is recombinated, has obtained a series of great achievement.



Development trend of mortality

Abroad Our country City Countryside

Gastric carcinoma is one of mankind's most common malignant tumour, according to the report which World Health Organization announced,

World gastric carcinoma annual morbidity 13.86/10 people Wan. Our country is the high taking place area of gastric carcinoma, gastric carcinoma is suffered from every year

Disease rate and mortality are more than 2 times of the average level in the world. Male morbidity and death of gastric carcinoma of our country

Person who die occupy various the intersection of tumour and have illness coming on and the first place of death, men and women than about 3: 1. Moreover, the eye

The mortality of gastric carcinoma of our country has been still on the rise ago, relatively death of gastric carcinoma of the seventies in the 1990s

Leading men to increase by 11%, women increase by 6.3%. The mortality of gastric carcinoma was slightly higher than in the city in the 1970s

The countryside, the countryside was higher than the city in the 1990s. Urban gastric carcinoma mortality ladies, gentlemen dropped separately in the 1990s

22.2% and 26.7%, and rural man, women rise by 26.4% and 22.1% respectively.

In contrast to it, the morbidity in U.S.A. and European country should be a bit lower, especially the fifties of the 20th century

And then, the continuation decline appears in world most countries in gastric carcinoma. U.S.A. was annual in the fifties of the 20th century

Mortality about 22/10 Wan, it drops 3.7/10 Wan to to be following the 1990s. There is Japan in recent years

Obvious downward trend, they adopt X-ray barium meal to check and sift and check with the gastroscope by fixed position, have improved greatly

Detection rate of the early gastric carcinoma.

People generally think, the decline of the morbidity of gastric carcinoma, change and electricity mainly with the meal way

The popularization of the refrigerator has something to do. One that is with social economy is developed constantly, some areas in our country are sure too

Change,such as Shanghai urban area morbidity of gastric carcinoma is for 62/10 Wan,there are for 23 on woman

. 9/10 Wan, and the intersection of men and women and morbidity drop 36/10 Wan and 18/10 Wan to respectively 1995, with the man particularly

The sex is obvious. But the one that should watch out for is, gastric carcinoma is approaching young people, the stomaches of young people of our country in recent years

Cancer accounted for the rate of all total number of gastric carcinomas already 1.7% of the seventies rose to 3.3% since last century.



Look for the antigen of gastric carcinoma by oneself

Find " MGAgs gastric carcinoma antigen " for the first time

There is not a final conclusion because of morbidity of gastric carcinoma at present, and early gastric carcinoma of the overwhelming majority is suffered from

Person have almost specific in any symptom,be be be in later period mostly already when the patient went to a doctoreddedded, so

The early diagnosis of gastric carcinoma becomes the important tactics which reduces the case fatality rate. Early gastric carcinoma has no symptom, do not have

Physical sign, get up disease hide very easy to leak, examine, leak, examine, leave tumour, spread, shift

Chance. Usually, should find the clues of gastric carcinoma in time, the gastroscope combines barium meal, angry barium to make

The shadow is the best inspection method. Gastric carcinoma find, can examine the gastroscope via gastroscope mainly in early period such as Japan

More than 50% of the total number of gastric carcinomas happen, but each inspection is spent high, it is ordinary to far exceed China

Common people's endurance.

Professor Fan DaiMing waited and studied gastric carcinoma from 1978, China did not find at that time that swollen

The antigen of tumour, introduce detection reagent of some important tumour antigen from foreign countries. But the order people finally

Disappointed, in pathological change before diagnosing gastric carcinoma and cancer, these antigenic function is very small, the positive rate is insufficient

40%, that the false negative rate is too high, still quite a lot of patients leak and examine. So they leave

It is determined to look for the antigen of tumour worth diagnosing from the stomach cancer cell importantly by oneself.

In order to look for the specific biological mark that can be measured in early days, the researcher employs the advanced lymph

Cells hybridize technology, have set up 28561 and hybridized tumour cells, has found " MGAgs gastric carcinoma for the first time

The antigen " . This kind of antigen has very high specificity on gastric carcinoma, the expressing rate is very high in gastric carcinoma is organized,

But hardly express in the normal organization. Dyed and verified by the immune group, its positive rate of histology

Higher than 90%, use for, measure MGAgs in the serum, patient of gastric carcinoma, positive rate can up to 70% so as to

Have, is 15 percentage points higher than similar method to employ more extensively at present.



Which are pathological change before the most dangerous cancer

The intestines of the mucous membrane of stomach grow and atypical hyperplasia

In the past, the postponement of diseases such as the gastric ulcer, stomach polyp and partly chronic withering gastritis,etc. healed,

Pathological change before mostly considering as cancer. These pathological changes are not rare in the crowd, but only a few people

The canceration will take place, moreover which one is distinguished there is trend of worsening quite difficult. Seeing that this seminar adopts

Organize pathology and immune group method to jointly employ clinical observation, come to appraise and organize taking place and gastric carcinoma

Progress. Free that the result reveals, the intestines of the mucous membrane of stomach are grown and atypical hyperplasia is in epithelial tissue of stomach

One is distributed and kept the same with height of gastric carcinoma. So, these are pathological change before more dangerous cancer.

Whether MGAgs is valuable as a kind of new tumour antigen, besides specificity,

Still depend on whether it can be used for clinical diagnosis and treated. For this reason, the seminar and domestic more than 10

Hospital and scientific research institute carry on close cooperation, appraise the clinic to gastric carcinoma of the antigen in an all-round way

Diagnose value. Clinical function research shows, these new antigen can assist the pathologic doctor effectively at first

To diagnosing the case not clear carries on differential diagnosis, distinguish the cancer cell. Second, they contribute to distinguishing

Two kinds have similar shape structure but different cancer cells take place in the tissue, here according to this doctor thereafter

The therapeutic method that the patient chooses will be different too. And the new antigen still can help to look for, appraise

Whether the unidentified transformation cancer of the lymph node reason comes from gastric carcinoma. Third, MGAgs can be regarded as the mark thing,

Pathological change, can measure to early gastric carcinoma before being used for screening and monitoring cancer of the easy canceration, and can examine

Measure the intravital gastric carcinoma focus.



Foresee gastric carcinoma ahead of time

MGAgs positive patient, 5 canceration rate is 30%

Our country carry on national cause of the death review investigation in 1973- 1975 year, find northwest the intersection of river and west walk

It is the gastric carcinoma hotspot of our country to be coastal in corridor area and the east. Subsequently, all parts and protect to the dangerous factor

Protect factor, go on, make investigations in a large amount, find dangerous factor have food with rich salt, go mouldy food,

Bad eating habit, the intersection of stomach and illness, family suffer from cancer history, mental wound and personality depressed, etc, and

There is factor on protective action for fresh vegetables, fruit, soyfood, milk and fresh fish, include

Garlic, spring onions and green tea of sulfhydryl- bases,etc..

Can MGAgs be used in the on-the-spot general survey of the high-risk group as a kind of gastric carcinoma serum mark thing

(used at the end of a special alternative, or rhetorical question)? Though the serological diagnostic method set up newly has value of better clinical diagnosis, but there are lookses

As a lot of gastric carcinoma patient can't detect, the main reason is MGAgs most is released into in the stomach, and

Do not release into the blood. In view of this, the researcher passes unremitting efforts, pass the living beings finally

Study the method, set up immune PCR technology, is used for measuring MGAgs in serum of gastric carcinoma, positive rate

More than 70%, some early gastric carcinomas can be detection too.

The seminar has chosen Pu open city Zhongyuan Oil Field, Gansu Province Wuwei county and Henan Province of Henan Province to be warm

The patient of county and other places found finally as the general survey target, dripped degree or positive MG high in serum

The colony of Ags can measure to gastric carcinoma, includes some early gastric carcinomas. In addition, pass the immune group

The method of melting observed the expression that MGAgs organized in the mucous membrane of gastric carcinoma to also get the following conclusion - -MGAgs

Positive patient, the canceration rate reached 30% in 5, but not as the few canceration of the patient of MGAgs. It's time to form

Fruit brief on, measure MGAgs can predict stomach mucous membrane know the canceration, so, it will probably succeed

In order to foresee one of the important signs of gastric carcinoma ahead of time. This technology has already been protected by national patent at present,

Have obtained new medicine and new achievement certificate, and obtained the country and invented the third-class award.



Explore biological therapeutic method

Vaccine of gastric carcinoma

Though chemotherapy is a main method to treat gastric carcinoma, the cancer cell can be produced and able to bear medicines. For this reason,

The researcher has studied the molecular mechanism of gastric carcinoma in an all-round way, has set up 4 kinds to oppose the cancer medicine and able to bear medicines for the first time

Stomach cancer cell department,last gene and expression albumen that is corresponding,and last a new one

Able to bear monoclonal antibody of the medicine molecule, can reverse the change of the stomach cancer cell partly. Recently, they

Have screened the phage and shown the random peptide storehouse, has obtained a large amount of ones that matched with McAb to clone, have

Clone, use for the small mouse of immunity succeed in producing antiserum. Verified by the immune group method, antiserum

Can combine with the human gastric carcinoma organization effectively, this has offered the base for the fact that DNA recombinated the construction of vaccine of gastric carcinoma

The plinth, and this vaccine will probably become one of the clinical biological treatment important means of gastric carcinoma.

Therapeutic method of traditional Chinese medicine

Western medicine have the intersection of Novartis and the intersection of pharmacy and dose rank, defend ' First sulfonic acid horse of Iraq takes the place of the Buddhist nun) : Glivec (imatinib) : Veenat of India.

Traditional Chinese medicine has soft hard oral liquid, subdue flat syrup of cancer, compound evergreen capsule, flat pill of anticancer, celestial toad slice,etc..
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