Clinical pathology and biological characteristic _ symptom of gastric carcinoma

Clinical pathology and biological characteristic _ symptom of gastric carcinoma
Gastric carcinoma is one of the most common malignant tumour, morbidity and mortality occupy the first place of digestive tract tumour. Pathology dividing systems of gastric carcinoma are numerous, the dividing type of the tradition is based on histologic characteristic of shape structure and cell, the gastric carcinomas of different organization types, its structure of shape and biological behavior are different, the epidemiology and molecule mechanism are also different. With the development of technology of modern molecular biology, biology permeates each other with pathology, the connection of the two is closer and closer, take shape gradually and is based on morphological method of traditional pathology, regard molecular biology characteristic as the new pattern of studying the focus.
First, pathologic credit type of gastric carcinoma
1,Daily dividing type: Existing gastric carcinoma pathology dividing systems are numerous, a commonly used one is to organize the shape credit type at present, there are Borrmann dividing into type, WHO dividing into type and Lauren dividing type,etc..
1.1 Borrmann dividing type
A fen type method that was put forward in 1926 by the German pathologist Borrmann, the main foundation tumour shape characteristic, other natural disposition and proportion of the endogeny the mucous membrane carry on the dividing type, it is 4 type to divide gastric carcinoma: Type (tubercle type) ,Tumour grows in, take the form of polyp, the basis is relatively wide, the realm is relatively clear, ulcer is rare, but there can be rotten the small one, the this type is the most rare. 2Type (ulcer limitation type) ,Tumour has larger ulcer that takes shape, the edge rises obviously, the realm is relatively clear, turn towards and can not soak obviously around. Type (soak ulcer type) ,Tumour has obvious ulcer that takes shape, the edge part rises, is soaked and destroy partly, realm unclear, to soak relatively obvious around, cancer organization range that soak exceed the border of tumour being seen of naked eye under mucous membrane, it is a type seen more most. Type (fill the air soak type) ,Present person who fill the air infiltration grow, confirm the intersection of tumour and border while being difficult, because cancer cell fill the air, soak and fiber organize hyperplasia, cause the coat of the stomach to increase thick, stiff, call " leather bag stomach " . Borrmann dividing type is a fen type method with classical gastric carcinoma, still adopt extensively in the world at present.
1.2 Lauren dividing type
Lauren divided gastric carcinoma into intestines type and filling the air type according to institutional framework and biological behavior of gastric carcinoma in 1965. Enteric gastric carcinoma originated from the intestines to grow the mucous membrane, generally there are obvious glands that are in charge of the structure, tumour cells take the form of column or cubic shape, it is obvious that pastes up form reason, tumour cells secrete the acid mucus material, similar to the structure of intestinal cancer; Often give birth to with withering gastritis and intestines, see more old men, the course of disease is relatively long, the morbidity is relatively high, the prognosis is better. Filling the air gastric carcinoma originated from the inherent mucous membrane of stomach, the cancer cell split up worse, presented filling the air growth, lack cell, connect, form gland, in charge of seldom, a lot of low to split up the intersection of gland and cancer and India give up cell cancer belong to the this type; See more young women, apt to shift, shift with the distant place the lymph node, the prognosis is relatively bad. Henson,etc. [1 ] in U.S.A. investigation reveal enteric morbidity of gastric carcinoma in the intersection of U.S.A. and man, woman, present the downward trend in descendants and white man, and filling the air gastric carcinoma is on the rise in the equal crowd, the morbidity rises to 1.8/100,000 of the people in 2000 from 0.3/100,000 of the people in 1978, among them the increase that India of Israel gives up cell cancer is most obvious. And research show, part person who fill the air gastric carcinoma has family's assembling and heredity, department's chain of house discovers department's mutation of CDH1 genetic embryo is its pathogenic factor. Lauren dividing type not only reflects the biological behavior of tumour but also reflect its cause of disease, pathogenesis and the characteristic prevails. Another advantage of deserving the dividing type is to live and examine and organize the dividing type of gastric carcinoma under the all right gastroscope of use, guide the surgery treatment [4 ]. Lauren dividing type is concise and effective, often adopted by the western countries. But there are 10%- 20% of the characteristics with the enteric type and filling the air type of case, it is difficult to include in any kind among them, thus is called the phenotype.
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