The mystery of tumour and cell metabolic disorder is untied

The mystery of tumour and cell metabolic disorder is untied
Xinhua News Agency Beijing Cable (reporter graceful jade of week of February 15) Cell reliance glycolysis of tumour carries on the supersession, but what has caused glycoclastic emergence? Coordinate the medical college an item of latest research results of Institute of Basic Medical Sciences and help to unlock the mystery that unusually the supersession grows in tumour in Beijing.
This important research results which the research group which regards doctoral candidate Sun Qian as main force that Professor Zhang HongBing led makes, issue on this week>. Discover, the mould plain target albumen of thunder handkerchief unusually activated produces M2 type third ketoacid kinase through inducing, thus cause the aerobic glycolysis take place in tumour cells. This discovery has offered a kind of new tactics for treating the tumour.
Zhang HongBing introduces, such supersession disorder phenomena as patient lighten with the high, weight of the energy consumption tumour more. In the twenties of last century, the supersession that the tile Burger of winner of the Nobel Prize of Germany Otto found tumour was organized was obviously strengthened, tumour cells mainly rely on glycolysis to carry on the supersession, it consumes candy speed and is far greater than normal cells. Characteristic of this supersession is that the reason why cancer is produced is still the result that the cellular metabolism of cancer changes on earth, it is the difficult problem of perplexing the medical circle for a long time.
In recent years, the supersession anomaly of tumour causes people's attention again, this kind " L The tile Burger's effect " R Begin to become the focus that tumour studies again. The Harvard University scientist finds M2 mainly existing in tumour cells Type last tumour cell third ketoacid kinase " L The tile Burger's effect " R Emergence,and play an essential role to forming and growth of tumour, but tumour cells produce the cubic meter type inducement of third ketoacid kinase not very clear.
The group that Zhang HongBing led is engaged in thunder handkerchief mould plain target albumen signal thorough fare and tumour taking place and therapeutic research for a long time. The mould plain target albumen of thunder handkerchief, as the protein kinase pivot of forming a connecting link in a cell, mainly adjust the growth of cell through combining growth factor and nutrition signal. It is out of control that many kinds of original cancer genes will cause the regulation of the thorough fare of this signal after activating, restraining the genetic inactivation mutation of cancer, excessively activate, thus cause various diseases, especially the emergence of tumour.
They discover, it is to lead to the fact tumour cells take place that the mould plain target albumen function of the thunder handkerchief is hyperfunction " The tile Burger's effect " R Key factor, study, define thunder handkerchief mould plain target albumen to promote M 2 type third the intersection of ketoacid and table of kinase by raising several proteins playing a main role while taking place at the tumour further Reach and glycoclastic emergence, jointly block thunder handkerchief mould plain target albumen thorough fare and glycolysis and can inhibit emergence and progress of tumour in coordination, inhibit the newly discovered tumour medicine target might increase the curative effect against tumour medicine, reduce the side effect and lower the drug resistance of tumour jointly.
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