Hydrazine crooks the piperazine and treats the _ treatment of hypertension

Hydrazine crooks the piperazine and treats the _ treatment of hypertension
[Medicines name ]Hydrazine crooks the piperazine
[English name ]Hydralazine
[Another name ]The intersection of hydrazine and the intersection of phthalein and piperazine, trap benzene rattle away piperazine, than west forest, Apres01ine, APressine A
[Properties ]White or faint yellow crystallization powder, without bad smell, there is bitter saline taste, soluble in water, are soluble in ethanol a little, 2% aqueous pH is 3-4.
Oral administration is absorbed fast and complete, the medicine density of blood of 1- 2 hour reaches peak value, the peak is identical with stepping down that blood medicine reaches the time of peak. The effective blood density is 100mg/ ml. The combining rate of plasma protein is about 90%. The majority and passes the base supersession in the liver by acetylation. Within 24 hours, discharge supersession product about 75% in urine, simple medicine only 1% or one 2%. T1/ 2 is 2- 3 hour. The medicine density of blood of 2- 3 hour reaches peak value after releasing a block of clothes slowly.
[Function and use ]
This product can relax the smooth muscle of arteriolar blood vessel directly, expand the blood vessel, reduce the resistance of peripheral blood vessel, make blood pressure drop. The diastolic pressure drops and drops more obviously than systolic pressure; Accelerate the diastaltic heart rate sometimes; While blood pressure drops, the cardiac output increases, the heart, brain, kidney and viscera blood flow volume increase, and divide with the renin into and ooze increasing and water and sodium retention.
[Usage and consumption ]
1. It is intermediate to severe hypertension, especially hypertension not complete to used in with high diastolic pressure of renal function. Take orally: 25- 50mg/ time, 2 times a day; Child is 0 every day. 75mg/ kg, divides into clothes 3 times. At the beginning should pharmaceutical block as receptor and oh share piperazine diuretic.
2. Treat the hypertension crisis that the poisonous blood disease of gestation or acute glomerulus nephritis causes. Skin note: 10- 20mg/ time, repeats once 6 hours later if necessary. Quiet note: 10- 40mg/ time, injects or dissolves into 5% of the glucose parenteral solution and instils slowly slowly. Child every day 1. 7mg/ kg, the clothes once of mark.
[Attentive matters ]
1. Tachycardia, patient and pregnant woman in heart failure, nurse women to forbid.
2. It is used that hypertension of high kidney disposition, coronary sclerosis, brain vascular sclerosis patient are careful.
3. Angina pectoris, myocardium infarction medical history and mitral stenosis patient can't use this product alone, should block pharmaceuticals to share with receptor.
4. There can be palpitation, have a headache, congest etc. dizzy, nausea, nasal mucosa, the incidence is relatively high.
5. The spiritual disorder appears once in a while, liver function is damaged, been allergic, generated heat, reduce etc. erythrocyte, leucocyte and blood platelet. A large amount of long-term administration will cause rheumatoid arthritis, sowing scattered lupus erythematosus and syndrome,etc., should stop medicines immediately, add cortical hormone if necessary. The dosage seldom appears when lower than 200mg/ day.
[Preparation ]
Tablet: The intersection of 10mg/ and slice, the intersection of 25mg/ and slice, the intersection of 50mg/ and block
Injection: 20mg/ ml
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