The lung can be tasted too taste Develop and mean the direction for new medicine of asthma

The lung can be tasted too taste Develop and mean the direction for new medicine of asthma
Lung can too " Smell " Taste happens? Organizing the report on October 24 of network according to the American physicist, the researchers of medical college of U.S.A. Maryland university find, the bitter tasting receptor not only exists on the oral cavity, there is the lung. Find out about the function of receptor of such new sense of taste, will bring new therapeutic method to asthma and other obstacle pulmonary tuberculosis. This research results are published on the " natural medical science " magazine websites on October 24.
Trachea whether air pass in and out passway of lung, and asthma trachea of patient breathe the skin to shrink, hinder the air flow, cause breath to urge to become reconciled and wheeze short. In study, regulate trachea, shrink in the human lung muscle receptor in relaxation finding the receptor of sense of taste accidentally research group.
The receptor of sense of taste on the tongue forms a cluster and was born in the gustatory bud, feel signals can be conveyed to the brain; In the lung, the receptor of sense of taste does not cluster in the gustatory bud, does not deliver signal to the brain either. Receptors of sense of taste of the lung all react to bitter tasting material like tongue receptor on, but it is greatly different to react.
First author of thesis, medical science and physiologic professor, heart and lungs genome plan director Stephen and Ligget of Maryland university medical college say, they think lung sense of taste function and tongue of receptor similar at the beginning, will invade and send out the warning to the noxious substance, namely after people suck the bitter tasting noxious substance, the thorax will be nervous to shrink, cause cough. But researchers find after activating the bitter tasting receptor of lung with some standard bitter tasting materials already known, their function is opposite with expectancy, not only has not shrunk the thorax, make its relaxation held instead. Ligget say they open trachea from depths, treat asthma or chronic obstacle pulmonary tuberculosis (COPD) using for Medicine open and have dark. This discovery may bring brand-new therapeutic method, develop new medicine which treats asthma, pulmonary emphysema or chronic bronchitis, or improve the curative effect of medicine used at present.
Researchers find in the experiment, quinine and chloroquine of medicine curing diseases such as malaria,etc. is very bitter, these medicines can all open the trachea already shrunk from the depths. And in the relaxation trachea, bitter tasting pharmaceutical in the fog pharmaceutical form has potentiality even more in treating asthma. But Dr. Ligget reminds people, bear hardships the food of flavor can not treat asthma. "We think, bitter tasting fog pharmaceutical that can be inletted into the lung by the patient after chemistry is improved is a best medicine. "
It study still find, at lung sense of taste receptor at the time of activation,function of calcium contrary to traditional idea. Pan Germany says that another author, medical associate professor of Maryland university medical college guide Park and wear Sri Lankan, people have thought, calcium will result in breathing skin cells to shrink while increasing, but discover newly, the bitter tasting material has increased calcium, but can make trachea muscles produce relaxation in a unique way, this show the intersection of lung and the intersection of sense of taste and receptor and lie in the intersection of cell and a kind of special calcium pool of edge have passway that is linked. (often beautiful monarch)
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