The all right quilt of cell suicide of tumour " L Induce " ?

The all right quilt of cell suicide of tumour " L Induce " ?
Staff reporter Tan Jia How could kill tumour cells? Perhaps many people will all escape one's lips : Radiotherapy, chemotherapy .
Radiotherapy, chemotherapy are all to encircle and suppress and destroy tumour cells from the outside. And the professor presided over first by Zheng Germany of Institute of Basic Medical Sciences " Cells wither and die to adjust and control studying with the tumour treatment " R Open up the path separately, utilize characterized withering in the mechanism of dying of cell, it induces tumour cells to explore " L Resolve oneself " R New route. This research results are obtained recently China's medical scientific award second prize of 2008 .
The all right quilt of the cell suicide " L Induce " R
" It is the suicide of cells that cells wither and die, this is a kind of normal physiological behavior. " L De Zheng Professor say death of cells is nothing more than two kinds of situations first: " R The homicide " L Sum " R Commit suicide " . " L The homicide " Utilize external factors such as chemistry, living beings, physics,etc. to cause cell necrosis. Cells wither and die to belong to " L Commit suicide " ,It is the natural death of cells in the course of growing. If the mankind originally connects on a finger of embryo together, one that is with cell among the finger is gradual to wither to die, 5 fingers could be separated gradually, each independence. Cells wither and die the phenomenon exist too in development and growth of other organism, if tadpole turn frog into need, take off tail, and tail can break away from, break away from the intersection of position and cell wither result of losing. Leaf from green to turn yellow until course that wither whether cell wither life course of losing gradually too.
The mechanism reflect particularly outstandingly while human body's immune cells turn into that cells wither and die. Zheng De says first, if there are the unripe or immune cells not complete of function that enter the human immune system, these cells may present " L Acknowledge friend as the enemy " R Miss,emergence that be caused on oneselfed on diseases immune. And the intersection of human body and immune cell in the course of splitting up ripely, have 95% unripe cell of the above wither mechanism of losing the organism through cell just probably " Remove oneself " ,Remove a hidden danger. Different from causing cell necrosis and the serious inflammatory response take place in external factor, cells wither and die to reflect any inflammation, one that it is the organism adjusts and controls the course normally oneself.
Soon after the cell theory was born in the 18th century, cells withered the phenomenon of dying was found immediately too, but study cells, it " L Death " R Meaning all the time little people make inquiries. What the researcher paid close attention to more are cells, it " L Grow " ,Such as growth, development, splitting up of cell,etc.. Begin will it be will it be initial stage the 1990s last century, world biology and medical field form cell wither climax studied to lose and sustain so far gradually.
" The main reason lies in people find it is not simple that cells wither and die ' die, death ends all trouble ', but have important physiological meanings. Cells wither and die and is controlled by the gene, and conduct the life and death that the course is handling cells through a series of signal. " Zheng De says first.
Any cell has certain life-span, it has steady cycle and proportion too that cell life and death is replaced. If the life and death of cells is out-of-balance in proportion, cells " L Grow and die few more " ,Cause cells to pile up in a large amount, just mean pathological change has taken place in the organism.
" Tumour is the generous piling of tumour cells, cells are damnable and not dying. " L De Zheng professor say, utilize cell wither, lose mechanism explore the intersection of tumour and avenue of treatment first, only " R The ones that let cells be damnable die " ,Should avoid a large number of life-expired cells are on one's last leg, leave the disaster.
Discover, the conditions of certain living beings, physics and chemistry that if offer, the suicide of cells is a all right quilt " L Induce " R (used after an attribute). It is causing the injury to normal cells at the same time that treatment means such as present chemotherapy, radiotherapy are killing tumour cells. And it induces tumour cells to pass " L Commit suicide " ,Would not injure normal cells, can overcome existing treatment means " L Enemy and we do not divide " R Shortcoming. This is that the principle of utilizing cells to wither and die treats the outstanding advantage of tumour too.
Have already applied for the clinical trial in relevant achievement
1995, De Zheng wait for the intersection of Chinese and scholar take the lead in, begin, wither, lose research of field in cell at home first, successively here>Wait for the foreign famous academic periodical to publish many theses, the research results are approved by people of the same trade at home and abroad.
The scientific research in the laboratory finds that inspires the heart, but only the first step taken in long march of ten thousand li. The project team that Zheng De headed first has not halted, but combine closely the basic research with clinical practice, in wither, die at the serial medicines of the principle are researched and developed on the basis of cell, the soluble tumour necrosis factor of recombination of having independent intellectual property right of the invention is correlated with withering to die to induce matching the body (trace) Mutant polypeptide, gland relevant virus (AAV) -TRAIL recombinates virus and a new resisting TRAIL receptor (DR5) Monoclonal antibody. 3 kinds of experimental therapeutic medicines have specificity that wound cell function of tumour and good clinical application prospect.
" Scientific research should never be only satisfied with doing the experiment, sending the thesis, we hope to turn the achievement of the basic research into medicine development in time too, benefit the society. " Zheng De says first.
Zheng De introduces first, recombination TRAIL mutant polypeptide researched and developed at first is studied before already finishing the stage in the laboratory and clinical, the curative effect that the specificity kills tumour cells is very good. The stage in the laboratory discovers, such mutant polypeptide is induced and withered on the function of dying to about 50% of the many kinds of tumour cells. If can succeed in developing into a medicine, the range of its indication will be very extensive. The medicines manufacturing enterprise has already supervised the administration bureau filing the clinical trial and applying to national food medicines at present.
The tumour treatment medicine of the principle research and develop and win the first battle to wither and die on the basis of cells, no matter how peptidic but should recombinate sudden change there is the weakness: The medicine is relatively short in internal half-life, curative effect is difficult to be lasting. Researchers imagine boldly whether could utilize virus carriers to transport this mutant polypeptide into human body, make it form in body " L The pharmaceutical factory " ,Go on constantly " Mutant polypeptide of trace " R Production,combine and induce tumour cell suicide?
The experimental result has supported their imagination: At animal experiment stage, thing of this gene therapy can last in the body " L Production " In more than 6 months, and can kill tumour cells effectively. Study stage before already entering clinically in research and development of this kind of gene therapy thing now.
" Though experimental result pleasant, improve space also greatly. " De Zheng say, urge the intersection of tumour and the intersection of cell and TRAIL lost to wither combine with tumour and cell surface receptor and produce and act on first, there are 5 kinds of known tumour and cell surface receptor at present, last thing TRAIL polypeptides mutant and pass what has been developed earlier stage experiment mainly with among them 2 kinds of receptors are combined then give play to curative effect. So, the third stage researches and develops and puts in strengthening and treating the thing specificity especially, hope that thing can treat
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