Plump type myocardium disease hypertrophic cardiomyopathy HCM_ general knowledge

Plump type myocardium disease hypertrophic cardiomyopathy, HCM_ general knowledge
Summary
Plump type myocardium disease (hypertrophic cardiomyopathy, HCM) Unidentified reason full of obstruct, ventricle with the intersection of scheming and the intersection of asymmetry and plump, the intersection of left ventricle and blood diminish and the intersection of relaxation and issue comply with, drop to myocardium disease of characteristic. Whether can be divided into obstructing and not obstructing plump type myocardium disease to obstruct to flow out one according to the left ventricle, unsymmetry interventricular septum plump to cause the intersection of aorta and petal lay getting narrow to claim special getting plump hair aorta one downed narrowly. It is often the reason why the youth dies suddenly that this is ill, crowd's morbidity is 0.02% to 0.2%, the good hair is 30~40 years old, there are many ladies to gentlemen, but women have illness coming on age is younger.
Cause of disease and having illness coming on in the not Ming of cause of disease of the mechanism. Think the inherent cause is the main cause of disease, its basis is inclination of having obvious family naturing that has illness coming on of a disease at present, often amalgamating deformity of other inborn cardiovascular vessels, some patients have a disease promptly when being born in, can see the hereditary genotype of HLA antigen in patient of this disease. Family's venereal disease example is transmitted in hereditary form of the autosome dominance, the pattern of the onset but the myocardium unsymmetry which does not have symptom is plump, there can also be typical obstructing symptom.
The hereditary defect causes the mechanism having illness coming on to have the following imaginations: Catecholamine and sympathetic nervous system unusual, evidence its exchange for disease this companion go crazy ridge organize disease, first overbearing insulinogenic hypersecretion, hypertension, block pharmaceuticals effectively with receptor. Proportional a interventricular septum of foetus increases the thick and myocardium fiber and can not arrange neatly, have not shrunk back normally after born in. It has caused the interventricular septum and free wall of the left room rapidly that the room room has been conducted out of step and excited and shrinking. Primary collagen unusually causes the unusual fibrous support of heart, make the myocardium fiber arrange disorderlily. The myocardium albumen is formated unusually. The small coronary artery is unusual, it is ischemic to cause, fiber and compensating myocardium one's elder. Interventricular septum protruding in the intersection of apex of the heart and the intersection of bottom of heart and axial protruding Left deviation to face left sideways ' Concave left when being normal) ,Do not wait long while shrinking, cause the myocardium fiber to arrange disorderlily and somely and plumply. There is not a distributing case of the family or hereditary evidence, its pathogenesis is not so obvious.
Pathology changes1,Dissect the left ventricle on the whole and is most often given much trouble, the myocardium weight increases, the cardiac muscle is plump can happen on any position of the left room, it is plump to organize the locality asymmetry the cardiac muscle, the ventricle is diminished, the whole ventricle is plump and relatively rare, there is plump more interventricular septum, account for more than 50%, the cardiac muscle of interventricular septum is plump, or plump in the underpart in the middle part of the interval, the thick one can reach 3cm, the prominent and plump interventricular septum causes the left room to flow out one and obstruct. Secondly apt to give much trouble position left the intersection of room and the intersection of apex of the heart and department ' Plump type myocardium disease of the asymmetric apex of the heart) , ventricle free wall, papilla skin ' It is often singly) , atrium. Some cases expand the left room in course of disease in later period, is called the plump myocardium disease and expanded one.
[1]' >Next page
|