There are ethnic difference _'s symptoms in the plump type clinical manifestation of myocardium disease

There are ethnic difference _'s symptoms in the plump type clinical manifestation of myocardium disease
The research of University of Hong Kong H o,etc. shows, Chinese's plump type myocardium disease (H C M) Manifestation different from white race,many and belong to characteristics such as difference,etc. of transferring women patient to to have having illness coming on late, apex of the heart parts of plump patient. ( A m J M e d 2 0 0 4 , 1 1 6 : 1 9 ) H C M is a kind of common disease, but in different crowds, its phenotype and genotype characteristic are widely different. Complication of H C M has dying suddenly, progressive heart declining, thromboembolism brain medium-sized soldier of quiver companion of room. However, most patients have not or only had a relatively lighter limited activity. In the white race, compare with the plump and other types in the middle part of the plump and left room of apex of the heart, the most common type in it is asymmetric and plump that the interventricular septum is plump. At present, other of materials limited about Chinese H C M clinical manifestation characteristic, the clinic of the bad incident happens to predict the factor is not clear.
The researcher includes in 118 Chinese patients (62 men) diagnosing as H C M in queen Mary hospital between 2002 and 1973 altogether . Diagnostic standard in the H C M one,in except caused by the fact that disposition or systemic disease continues the hair room wall plump behind, the supersound or magnetic resonance imaging reveals, a left ventricular wall is some in relaxation or it is greater than or equal to 15 m m that the filling the air is plump. One is defined as dying suddenly H C M relevant main energies' running affairs, because the not normal death of rhythm of the heart, the heart declines, quiver relevance apoplexy of room, potential the intersection of mortality and arrhythmia and need difficult person who manage of heart transplant heart decline or pass through leather interventricular septum melt H O C M that skill treats (obstruct obvious symptom, and the medicine fails to respond to any medical treatment) . The cardiovascular complication including room correlated to H C M is quiver, the heart is declined, that room a quiver and relevant one of arrhythmia, room of mortality is not that the mortality soldier neutralizes membrane inflammation in the infective heart.
The result reveals, H C M patient's morbidity mean age is 54 for 18 years old, follow up a case by regular visits to 5 on average. 8 4. In 3, there is no obvious difference on behaving in two groups men and women's demographic materials, clinical characteristic and supersound. The patient of 14 has history of H C M family, patient of 72 have symptom, 28 have symptom, find electrocardiogram to be abnormal accidentally during physical examination or auscultation has heart murmur.
The abnormal one of electrocardiogram takes 85, among them is shown as the plump one of left room takes 60, T personned who inverts wave takes 69, enormous to shoulder to the intersection of T and wave taking 26, bunch prop up block, take 11. Most common type apex of the heart plump ' 41 % ) ,Secondly for the intersection of unsymmetry and plump interval ' 31 % ) , plump to the disposition ' 14 % ) Or other type ( 14 % ) . Left room average diameter ' 37 8) M m, the interventricular septum thickness is (18 7) M m, the wall thickness is behind the left room (12 3) M m, patient of 15 have left room flow out line, obstruct (pigeonhole difference> 30 m m H g under the quiet the intersection of interest and state) .
10 patients die during following up a case by regular visits to, 9 among them correlate with H C M, the annual case fatality rate of the cardiovascular reason is 1. 6, in these 9 patients, 8 are women. In following up a case by regular visits to, run affairs in main energies a incidence is 16, the annual incidence is 2. 8 % .
It is single variable analyze whether reveal,women, last dish to last> 30 m m H g H C M, interest rooms lefts quiet of apex of the heart, the clinic of one of running affairs of the main energies happen and predict the factor. After many variable analyze, women only prominent the intersection of prediction and factor (H R 5 only. 8 6 , 9 5 % C I is 1. 7 7 - 7 . 21 ; P =0 . 007 ) . K a p l a n - M e i e r curve reveals, run affairs in women H C M patient's main energies a incidence is higher than men notably.
The patient of 84 has accepted drug therapy in this research, the patient who among them takes receptor and blocks pharmaceutical takes 72, anticoagulatory pharmaceutical takes 29, the calcium passway blocks pharmaceuticals and takes 27, amine iodine ketone takes 16. The patient of 5 puts into the burying type and replies the law defibrillating device (I C D) ,The patient of 9 puts into the pace maker.
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