Alveolus protein deposits the treatment _'s treatment of disease

Alveolus protein deposits the treatment _'s treatment of disease
How directed primarily to to remove the calm albumen - like material in the alveolus. Use one pair of tracheas conduit (Carlen conduit) in recent years Or fine to prop up mirror, make one side lung or physiological saline of lobe of the lung, irritate and wash, hocket regularly. Recent curative effect reveals patient's dyspnea and lung function improve, half the number patient X-ray chest slice is variable and clear. The long-term result majority keeps relieving the state, a few patients recur, often within 6- 24 months, can make the lung to irritate and wash again.
Protein calm disease (Pulmonary alveolar proteinosis, PAP) of the alveolus It is one that breathe disease rarely, end calm a large number of the intersection of surface and active albumen and lipid under detailed bronchus of breathing etc. as the characteristic with alveolus. According to have illness coming on, can divide primary PAP into and continue two of PAP of taking place etc. it. Then the treatment principle of sending PAP has illness coming on originally in order to treat.
As to sending PAP originally, define effective therapeutic method is that the bronchus alveolus is irritated and washed, wash and remove calm protein and lipid in the alveolus through irritating. Its result depends on the lung irritates the washing amount, divides the whole lung of side of form once to wash hands and face and prop up the mirror to wash hands and face effectually more finely. However, it is unable to accept this therapeutic method when patient's lung function is damaged seriously. It reason seldom has gas that can be exchanged in one side lung to wash hands and face, the result causes hypoxemia disease to even breathe depletedly. Though can choose the extracorporal circulatory system or carry on the whole lung and irritate washing in the hyperbaric oxygen cabin, but will increase expenses and complication, it is not easy to operate either. In addition, the residual liquid can reach 0.5-1.0 liters, take 2-3 days to absorb clean in the lung while pouring into finishing, also will influence patient's breathing function.
Insufficient for overcome these, it tries out general anesthesias that oneself improves to be airtight to pressurize, give oxygen divide the intersection of side and the intersection of lung and skill of washing hands and face into from 1999, that there are 2 pieces of important improvement in the new method with the difference of past methods: 1, The lung offers airtightly and pressurizes to give oxygen while washing hands and face. Behind pouring into the physiological saline to the total amount of single side lung in the lung, pinch for oxygen to keep exhaling at the same time manually the end is keeping 5 centimetres of water columns, make pure oxygen among them and wash hands and face in the alveolus liquid mix after the 30-60 retrieving, washing hands and face liquid fully. 2,In for the first time with washing hands and face in the liquid twice expire, wash hands and face in the liquid putting Epinephrine (1mg/L) into in physiological saline .
Improve three pieces of beneficial function first: ( 1) Make, wash hands and face liquid with alveolus fully keep in touch, increase the result of washing hands and face; ( 2) Improve oxygen, shut function, suitable single the intersection of side and lung keep in touch with, can't keep partial pressure of oxygen in safe range person especially. Because it can make pure oxygen mix in the liquid, contacts with the alveolus abundantly and increases oxygen to shut. If degree of saturation of oxygen is reduced in the skill, except adjust and does not wash hands and face the density of oxygen intake of the lung and breathing and supporting the parameter, should also increase and wash hands and face giving oxygen and pushing time of the side of lung. ( 3) While washing hands and face in the side of lung and pressurizing and giving oxygen, the mitigation flow that but because of rising of pressing in the alveolus and improving the partial pressure of oxygen of arterial blood. Second beneficial function that improve until physiological saline wash hands and face in the liquid putting into the Epinephrine, not only help the intersection of relaxation and bronchus and retrieve, wash hands and face liquid; And help to absorb and remain the liquid in the alveolus, reduce its impact on breathing function.
The new method has already been applied to a few patients at present, make the obvious result.
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