The alveolus albumen deposits the cause of disease of disease and _'s general knowledge of pathogenesis

The alveolus albumen deposits the cause of disease of disease and _'s general knowledge of pathogenesis
According to the report, suffer from the person who deposits disease of alveolus albumen from the babies of 7- 8 months to 72 -year-old old man, but mostly 30- 50 years old person. Men are about 3 times of women's. Analyze the granular and wadding indicated to deposit in the alveolus, belong to lipoprotein with the pulmonary surfactant, rich in phosphatide, it is periodic acid Heav dyes strongly and positively, both basically the same too on the chemical constitution. Under the electric mirror, the calm thing of alveolus is not the amorphous one completely, but a lot of change the little body of one layer of forms, in other words periodic acid Heav being seen dyes the positive particle under the optical microscope, the same as changing the little body of one layer of forms in the alveolus cells of Model me. Therefore imagine, this disease results from the reason that the pulmonary surfactant is excessively secreted and removed and slowed down, it is may the unusually type pulmonary surfactant. Find, the pulmonary surfactant is drained into the alveolus after being emerged by Model II cells through animal's experiment. When the albumen of alveolus of experimental animal deposits disease, this kind of course drained into the alveolus is strengthened. Drain alveolus into change the intersection of layer and low body, engulf macrophage rapidly, macrophage swell, its energy were weakened notably, broke at last, then changed the layer small body to store up in the alveolus constantly, get the alveolus albumen and deposit disease. Therefore alveolus remove mechanism fail, may take place too copies of important reason of disease one of change layer little body lose activity after deal with macrophages, and can inhibit the activity of the pulmonary surfactant. Seeing that about half the a patient often contact various dust or harmful gas, and suck for mice for a long time with silicon dust, can make animal suffer from the intersection of alveolus and albumen, deposit disease, think copies of disease may alveolus to getting chemical a amazing one the specificity react. But still about half case does not have this clue, so the precise cause of disease waits to further explore. The lung weight of disease increases, sink in water. Can see the alveolus and swell under the optical microscope. Alveolus. It is full of having a liking for the red particulate matter in Iraq breathing even small thin bronchus of thin bronchus, Heav dyes and presents strong positive reaction with periodic acid. Under the electric mirror, this kind of particle, in order to change the little body of one floor of forms. Alveolus wall and alveolus structure are normal, the neighbouring alveolus wall can see a large number of macrophages. Lung function check, present, keep in touch with the intersection of function and obstacle, maximum person who keep in touch with and exhale vital capacity ratio normal vital capacity hard while being restricted. The disperse function is lowered.
|