The original body of clothing of pneumonia can cause _'s prevention and health care of atherosclerosis

The original body of clothing of pneumonia can cause _'s prevention and health care of atherosclerosis
The Seattle epidemiologist Grayston of University of Washington in U.S.A. claims, the original body of clothing of pneumonia can cause atherosclerosis.
Study to find, all parts of the world have original body of clothing of pneumonia to infect in epidemiology, the majority were infected with 20 years old ago, it is very common too to be infected with repeatedly. Antibody will disappear automatically 3- 5 year after the infection for the first time, but 20 -year-old the intersection of people and the intersection of antibody and positive rate can be up to 50%, will also continue rising later; Old men can be up to 80%; 70% of women. The raised reason is not so obvious, but Grayston thinks, it may be the reflection of male arteriosclerosis with higher incidence. In 1988 Saikku,etc. found a coronary heart disease patient had obviously higher positive rate of original body serum antibody than the pneumonia clothing of control group, thus link it to coronary heart disease at first. Grayston finds, the narrow person who exceeds 50% of more than 1 coronary artery, the positive rate of antibody is higher than the normal one of angiography notably, and been verified the relevant relation between antibody and coronary heart disease by the test.
To come from South Africa and whole U.S.A. include white man, black person, inferior the intersection of state and people and original inhabitants in Alaska add up to the research of 362 one, employ immune cytochemistry (use specific monoclonal antibody of kind) And PCR (polymerase chain reacts) Arteriosclerosis and pathological change and sample waiting for the method to get to corpse examining, operation,etc., including coronary artery, common carotid artery, arteria femoralis, artery and aorta are measured, had not revealed finally that there is age difference of gender. 55% of the arteriosclerosis has original body of clothing of pneumonia while organizing; The electric mirror has also verified its existence, and isolate the original body of this clothing from pathological change. But normal artery and 31 totally without coronary heart disease control group find the intersection of pneumonia and the intersection of clothing and original existence of body in the sample. Have already suffered from porridge a kind of hardened coronary artery or heart to put up a bridge and isolate the original body of clothing of 18 of pneumonia in the blood vessel from 102 now, and further verify that there is original body of clothing alive that exists in pathological change to harden.
Two research which Finland and Canada carry on, main atherosclerosis appears behind inoculating a nose of rabbit against the original body of clothing of pneumonia. Inoculate twice the incidence than once is high, but there is no main arteriosclerosis in the control group of the false control group or infection mycoplasma that inoculates. M The main arteriosclerosis model rabbit that hlestein,etc. is induced by cholesterol divides into for 3 times, inoculates original body of clothing of pneumonia, aorta pathological change is obviously aggravated 3 months later. Offer after the 3rd inoculation to very mould persons who usually treat for 7 weeks of A, aorta pathological change is similar to control group, has not aggravated, it is obviously different to treat with the intensity of pathological change of persons who do not treat. Grayston give arteriosclerosis experimental mouse to inoculate clothing, find clothing original body want, exist 20 week at least in aorta behind the original body in the nose, find in pathological change that there is clothing original body, and infect mice to compare with contrasting mice, the pathological change range is obviously great, it has been already 1 time bigger than the control group in 16 weeks.
The above-mentioned result of study indicates, the original body of clothing of pneumonia can cause atherosclerosis, and can make the course of pathological change accelerate. The study on mechanism finds, the macrophages of person that trains outside the body can take in a certain amount of fat material, if cells have been infected with the original body of clothing of pneumonia, the quantity taken in is greater. A lot of macrophages infected are like the foam cells in plaque in morphology very much. Discover, harden in the pathological change having, regulating the intersection of macrophage and the intersection of tumour and the intersection of necrosis and factor and the intersection of ground substance and metal protease, expressing the intersection of clothing and original the intersection of body and the intersection of shock and albumen further, its function relates to atherosclerosis and complication. Someone find endothelial cell infect clothing behind the original body, cell and penetrating of monocyte strengthen to neutral grain. The experts in Toronto find, mouse myocardium peptide and clothing original external membrane albumen are the homology array on the structure, these two kinds of peptides will both cause mouse's cardiac muscle to damage seriously.
One discovers, use the morbidity that with effective original body antibiotic to clothing of pneumonia can reduce coronary heart disease previously. Two small-scale tests have verified too the antibiotic treatment can lower the morbidity of coronary heart disease. This supports a reason that the original body of clothing of pneumonia is atherosclerosis from the other side. For this reason, are carrying on two large-scale tests on clinic, in order to verify this question finally. Test the target as 3500- 4000 coronary heart disease patients making a definite diagnosis of it, observe time limit for more than 4 years. Half-life is long while employing cells, can give medicines once with every week, it is usually treated that with effective original body A to clothing of pneumonia is very mould. It is very mould and plain that the method is offered to 600mg A every week to the experimental group, the control group gives placebo. The difference of these two tests lies in being different for medicine time accidents, it is 3 months and one year respectively. Experimental the intersection of terminal and index die of illness for coronary heart disease, myocardium infarction, accept the intersection of blood vessel and coherent surgery or because steady angina pectoris hospitalized for treatment. Two these test, finish within 2- 4 years, can draw the clear conclusion while being natural when the time comes.
In a word, there are clear relations between original body of clothing of pneumonia and atherosclerosis, will clarify this question finally in animal's experiment and clinical trial.
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