The pneumonia streptococcus combines vaccine to infant and pre-school children's safe and effective _'s prevention and health care

The pneumonia streptococcus combines vaccine to infant and pre-school children's safe and effective _'s prevention and health care
Reports such as Finnish Wuorimaa,etc., it is safe to infant and pre-school children that 11 prices mix the carrier pneumonia streptococcus and combine vaccine, and there is original immunity.
Pneumonia streptococcus many the intersection of candy and vaccine to 2 children have immunity to be getting former, but limited in little results of infant and pre-school children. Combine vaccine, can overcome many the intersection of candy and the intersection of immunity and getting former shortcoming of vaccine. Infant and pre-school children combine the continuing, taking place immunoreaction to have the characteristics that T cells rely on of vaccine to the pneumonia streptococcus. May compete for carrier -specific T cells limited in quantity because of the fact that many prices combine the one of vaccine albumen group, it is comparatively difficult to increase and combine the price of vaccine. Use single the intersection of carrier and albumen might cause overload of carrier, because of lack enough carrier T, assist cell and reduce immunoreaction. And diphtheria combine many the intersection of candy and vaccine that mixture makes up may solve this problem by tetanus. Purpose of research this to appraise toxin make 11 the intersection of price and the intersection of pneumonia and streptococcus of carrier it combines vaccine to be original in healthy tolerance and immunity of infant and pre-school children with tetanus with diphtheria, and observe the original influence to vaccine security and immunity of aluminium adjuvant.
Vaccine adopted in this research is mixture of more than 11 kinds of glycoprotein combination. 3,6B, 14, 18C -type pneumonia streptococcus many candies are bound with diphtheria toxin; 1,4,5,7F, 9V, 19F, 23F -type pneumonia streptococcus many candies bound with tetanus toxin albumen. Vaccine of every pharmaceutical includes 1, 4, 5, 7F, 9V, 19F, 23F type many candies of 1 g; 3 g3, 14, and 18C many candy and 6B large candy of 10 g. 20 Finland and 23 called Israeli infant and pre-school children ' 13- 24.8 months) Combine vaccine after inoculating the pneumonia streptococcus that contain aluminium adjuvant or not. Security data for 5 days after the record is inoculated. The blood collecting of the 28th day, measure IgG antibody of many candies of 11 kinds of vaccine by enzyme vaccinating after and inoculated before vaccine inoculationing.
The result reveals, this vaccine does not have serious side effect. Compare with the vaccine not including aluminium adjuvant, there is less vaccine local response which contains aluminium adjuvant, but there is more whole body response. Two kinds of vaccine fill a prescription to rise notably to IgG antibodies of different more than candies in vaccine. It is the strongest that the 3 type and 7F -type immunity is original; The antibody density of the infant and pre-school children of vaccine inoculation reaches 1 g/ml. It is the weakest that 6B, 14, 23F -type immunity are original; Inoculate and does not include the aluminium adjuvant vaccine group ing has 36%, 27%, 32% antibody density of infant and pre-school children that reaches 1 g/ml separately; Inoculating and including the aluminium adjuvant vaccine group has 53%, 38%, 53% antibody density of infant and pre-school children that reaches 1 g/ml separately.
Lie between the influence led because of carriers, increasing the vaccine price may reduce the immunity originally. But observe the research this kinds of influence, it last antibody density where infant and pre-school children produce behind vaccine and last unit price, 4 price and 11 price tetanus and (or) It is similar in density that diphtheria combines the antibody that vaccine produces. The researcher thinks, it is safe to infant and pre-school children that 11 prices mix the carrier pneumonia streptococcus and combine vaccine, and have original immunity. The use of adjuvant of vaccine seems not to produce obvious beneficial function.
|