The alveolus albumen deposits disease and sums up _'s general knowledge

The alveolus albumen deposits disease and sums up _'s general knowledge
The alveolus albumen deposits disease (Pulmonary alveolus protein deposition sickness) ; A kind of rare disease. The alveolus has albumen - like materials that is deposited, presents pathological change in the lung. About 1/3 of the patients have no symptom, clinical manifestation generates heat, continue it with the intermittence one, present the going on and have difficulty in breathing later. Low-heat. Cough. Cough up phlegm. The chest aches. The weight is lightened etc.. X ray chest checks the similar acute lung of pathological change edema in the lung. Cause of disease bright, disease this named as, deposit disease by albumen by alveolus at the report for the first time on 1958, still continue to use this name of disease so far.
Cause of disease and pathogenesis suffer from the person who deposits disease of alveolus albumen from the babies of 7- 8 months to 72 -year-old old man according to the report, but mostly 30- 50 years old person. Men are about 3 times of women's.
Analyze the granular and wadding indicated to deposit in the alveolus, belong to lipoprotein with the pulmonary surfactant, rich in phosphatide, it is periodic acid Heav dyes strongly and positively, both basically the same too on the chemical constitution. Under the electric mirror, the calm thing of alveolus is not the amorphous one completely, but a lot of change the little body of one layer of forms, in other words periodic acid Heav being seen dyes the positive particle under the optical microscope, the same as changing the little body of one layer of forms in the alveolus cells of Model me. Therefore imagine, this disease results from the reason that the pulmonary surfactant is excessively secreted and removed and slowed down, it is may the unusually type pulmonary surfactant. Find, the pulmonary surfactant is drained into the alveolus after being emerged by Model II cells through animal's experiment. When the albumen of alveolus of experimental animal deposits disease, this kind of course drained into the alveolus is strengthened. Drain alveolus into change the intersection of layer and low body, engulf macrophage rapidly, macrophage swell, it is weakened that its energy are apparent, broke at last, then changed the layer small body to store up in the alveolus constantly, get the alveolus albumen and deposit disease. Therefore alveolus remove mechanism fail, may take place too copies of important reason of disease one of change layer little body lose activity after deal with macrophages, and can inhibit the activity of the pulmonary surfactant.
Seeing that about half the a patient often contact various dust or harmful gas, and suck for mice for a long time with silicon dust, can make animal suffer from the intersection of alveolus and albumen, deposit disease, think copies of disease may alveolus to getting chemical a amazing one the specificity react. But still about half case does not have this clue, so the precise cause of disease waits to further explore.
The lung weight of disease increases, sink in water. Can see the alveolus and swell under the optical microscope. Alveolus. It is full of having a liking for the red particulate matter in Iraq breathing even small thin bronchus of thin bronchus, Heav dyes and presents strong positive reaction with periodic acid. Under the electric mirror, this kind of particle, in order to change the little body of one floor of forms. Alveolus wall and alveolus structure are normal, the neighbouring alveolus wall can see a large number of macrophages.
Lung function check, present, keep in touch with the intersection of function and obstacle, maximum person who keep in touch with and exhale vital capacity ratio normal vital capacity hard while being restricted. The disperse function is lowered.
The clinical manifestation patient can have respiratory tract symptom at various degrees, generate heat, the going on has difficulty in breathing, cough. Cough up phlegm. The chest aches, the weight is lightened, take the blood in the phlegm sometimes. About 1/5 of the patients have illness coming on urgently and heavily, how due to erupting simultaneously and infecting. Physical sign the intersection of X and ray behave obvious as light, this characteristic of disease this, can have the intersection of lung and the intersection of underpart and wet transliteration relatively, can point cyanosis and poke in later period.
X ray behaves, the majority is dual side symmetrical detailed tubercle shade, pathological change is mostly merged, the realm is fuzzy. Many case pathological changes are radiated outwards from the lung door, take the form of butterfly, like the acute lung edema.
Diagnose and treat X ray pathological change of a disease like the acute lung edema very much, but lack clinical symptom and physical sign, the two are extremely unbecoming. The nearly rarely seen to deposit disease on the intersection of alveolus and albumen situation, diagnose difficult and big tentatively, alveolus irritate lotion act as the intersection of iodine and sour Heav dye, can support, diagnose further. But case misdiagnose for pneumonia often, clinical course can brief on, have copies of possibility of disease later, must depend on the lung and live and examine to make a definite diagnosis of. This disease must and lung edema,bronchus pneumonia, taking place specially distinguish the lung hemosiderin diseases and pulmonary tuberculosis calm,etc.s.
This disease does not have special treatment, patients of 60- 70% of the adults can resume by oneself, nearly 20- 25% of the patients die from to breathe depletedly 5 years, die of lung worry occasionally. Child's patient nearly all die. Cortical hormone is invalid to this disease. In recent years, use one pair of tubes to make the lung and irritate and wash the treatment, can obtain better curative effect, but can recur.
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