Can carry DNA compound and come out the expected realizing amount of genomic medicine is produced
According to U.S.A. >Bimonthly The publication (publish ahead of time) in November - December The report, Europe studies and coordinates the office (Ulika) Scientist compounds news with DNA,indicate whether there aren't a, sign of this break-through carries new medicine reagent of DNA and puts out for the first time soon.
Gene therapy refers to shifting the new hereditary information to damage or in the ill nucleus, programme cell again, so as to repair the cells damaged. At present, the scientist usually shifts the gene by three kinds of carriers while carrying on gene therapy: Virus carriers, going against to duplicate the virus carrier, non- virus or synthetic reagent carrier.
The genetic law depends on the virus' shifting" L Infect " R Come to realize, it changes the new hereditary information over to the most effective method of cells at present, but will inject much unfavorable information into cell in the course of shifting, so this kind of transformation method risk is very high. Though the non- virus or method of using synthetic reagent to carry on the transgenics may be accepted by body even more, but this kind of method is not high in the efficiency which enters the cell respect of injecting new DNA, and synthetic reagent very much difficult to realize and produce in enormous quantities.
Compared with other synthetic carriers, the new chemical reagent that EUREKA project group develops can send into DNA in the nucleus more effectively, and easier to produce in batches.
Project team members, Finland Hull hard medicine director of research and development centre Otto's Ecuador of base university mention explaining, when these compounds in solution state and add DNA among them, they will combine together. This big, fluffy DNA will be decomposed, combines and forms some particles with diameters of 10 nanometer to 50 nanometer with carriers. When sending the particle to cells, the nanometer particle assembles on the surface of cell, watch folds while facing cells, form a bubble bag in cells, then, the particle will escape from bubbles in the pocket, release DNA.
U.S.A. strange some Andrew of university scientist Sene say gene make up with group it mixes progress of technology to be at a tremendous pacing, but the tool which carries on gene therapy is very simple and crude. The scientist says, has experienced failure and disappointed field in gene therapy this these decades, the aforesaid breaks through and lets people see the hope. Though since 1959, people understand the technology which changes DNA, and the scientist hopes gene therapy can contribute in treating cancer, AIDS even cardiovascular disease, but it has not cured any kind of disease in fact. However, specific example indicates, gene therapy has produced the positive role while using in combination with other treatments. (Liu Xia )
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