's symptom that the early diagnostic method of pancreas cancer comes out

's symptom that the early diagnostic method of pancreas cancer comes out
In our country, pancreas cancer although loud to take the intersection of life and the intersection of cancer and evil spirit, but because it is difficult to diagnose in early days in it fearful. An important research that gi medicine of BJ Union Hospital has just finished can let people's fear be reduced slightly. The result of this research shows, unite excrement and urine cancer genetic K-ras and restrain mutation detection and tumour mark thing CA19-9 of cancer genetic P53 to test, probably find pancreas cancer in early days. Directly under recent Ministry of Public Health that holds (in charge of) In the unit clinical discipline key item is checked and assessed, the research obtains high evaluation of the evaluation expert. In recent years, the global cancer morbidity of pancreas rises year by year. Too domestic and foreign to break through in diagnosing for many years. Patient 3/4 belong to later period already during visit, survival rate fewer than 5% five year. If can diagnose and puts into and treats in early days, survival rate can reach 20%- 50% in five years. So, study new screening and diagnosis means, improve the finding rate in early days, it is the key to conquering pancreas cancer. Directly under Ministry of Public Health (in charge of) Under the support of the special fund of key item of unit clinical discipline, since 1997, the seminar of gi medicine of BJ Union Hospital headed by land star Professor Hua has carried on overall and deep exploration to the diagnosis in early days of pancreas cancer. They discover, have supreme diagnosis sensitiveness and accuracy through the pancreas cholangiography of duodenum; Many kinds of cancer genes or anomalies of restraining cancer gene and albumen of pancreas cancer are very outstanding. There is more than two kinds of gene unusual accounting for 18%- 47% in K-ras, P53, P16, but chronic pancreatitis does not have this kind of phenomenon; Through improving the excrement and urine DNA preparation method, can obtain PCR obviously higher than the foreign literature report and amplify success rate. On this basis, jointly employ the sudden change of excrement and urine K-ras sudden change and P53 to measure, diagnoses the sensitiveness of pancreas cancer can reach 93.2%, if jointly test with tumour mark thing CA19-9 an above-mentioned one kind of two detection, diagnose the specificity can reach 85%- 100%; T1 stage (tumour is confined to the pancreas, there is no lymph node to shift yet) verified by operation and pathology The patient's pancreatic juice, excrement and urine K-ras sudden change rate and P53 sudden change rate and T2 stage more than patients' resembling. Comprehensive above-mentioned research, they draw the conclusion, unite excrement and urine K-ras, P53 sudden change to measure and test with CA19-9, probably find pancreas cancer in early days. It is reported, relevant experts will be launching the high-risk group of pancreas cancer (above the age of 45 correctly next, send diabetes, chronic pancreatitis newly, smoking, there is family's history of tumour) Epidemiology investigate and it follow up a case by regular visits to,in order to proving on theying screening method to introduce.
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