The hereditary gene of cancer family of pancreas is found _'s general knowledge

The hereditary gene of cancer family of pancreas is found _'s general knowledge
Though the morbidity of pancreas cancer is low, it is often fatal, most patients die in one year after making a definite diagnosis of, die of cancer in U.S.A. and rank the 4th in disease. At least 10% of the pancreas cancer patients are thought to have inherent cause of family nature, such as hereditary variation, but the relevant gene has not been clear all the time. Recently, a research group engaged in the pancreas cancer gene for many years and search found this kind of gene. Terry of University of Washington? Brent and David of Pittsburgh university? Nurse, health of Waite, announce, they discover one genetic mutation to name palladin in one old family.
In 4 generations of this family, 18 members suffer from pancreas cancer or pancreas precancerous lesion. While tracking these patients own in common instead of existing in healthy members' bit of DNA, researchers lessen gene on the chromosome of the 4th to a relatively smaller range, including 243 known genes. They have made and can measure the genetic fragment in these 243 candidate gene expression levels, and more normal pancreas tissue and pancreas of cancer are organized (come from this family and other independent pancreas cancer patients separately) Difference.
Palladin is one of these 243 genes, research verifies it expresses high in tissue and other cancer patients of this family. It is named after Italian architect Palladio in the 16th century, relates to code cell framework (control cell shape and activity) . Subsequently, palladin RNA in researchers organize in coming from healthy people and pancreas cancer sample and previous patient of pancreas cancer of this family carries on quantitative analysis. The result indicates, palladin has ultra expression earlier in the person who didn't get hereditary pancreas cancer, and relate to cancer development of pancreas. Further analyze that finds, there is palladin that makes a variation in the pancreas cancer patient or previous patient of pancreas cancer of this family, and does not exist in ill members. Discover, mutant palladin can increase the migration rate of human cells in the laboratory, and make the skeleton of cells destroyed (the typical characteristic of cancer cell) .
These results prove, mutant palladin relates to emergence of pancreas cancer of this family. In addition prove, palladin gene exceeded and expresses and relates to morbidity of the non- hereditary pancreas cancer too. Regard palladin as " The pancreas cancer gene " Can know the cell procedure of pancreas cancer in terms of molecule, will contribute to improving to the diagnosis of this disease and improving to this treatment means of ordering disease unanimously.
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