The cause of disease of the plump type myocardium disease and what have illness coming on in the mechanism? 's general knowledge

The cause of disease of the plump type myocardium disease and what have illness coming on in the mechanism? 's general knowledge
Plump type myocardium disease can present the family and have illness coming on, there can also be distributing nature to have illness coming on. According to the investigation result of epidemiology, the persons who distribute account for 2/ 3, the person who has family's history accounts for 1/ 3. In the family patient having illness coming on, 50% of the plump type causes of disease of myocardium disease are indeterminate, rare in 50% of the house departments there is gene mutation. Hereditary way the dominant heredity of autosome is the most common, about ancient 76%.
(1)Inherent cause: Plump type myocardium disease is considered to be a kind of autosome dominant genetic disease, the onset mechanism is still indeterminate, think HCM is due to sudden change that is shrunk the relevant albumen of system by the myocardium sarcomere at present, study 10 encode the intersection of skin and the intersection of section and 300 the intersection of multi-type and sudden change of albumen, participate in emergence of disease this already so far. A myoglobulin heavy chain of B is a main pathogenic gene.
(2)The catecholamine and endocrine are disorderly: The catecholamine is produced too much, the myocardium organization, to its reactive increase. It is closely related with with cardiac muscle plump emergence and development that the gene expression of original cancer is unusual.
(3)Calcium is regulated unusually: High blood calcium often coexists with plump type myocardium disease ' 47% - 72% ). Calcium is regulated unusually and participated in the plump type myocardium disease to have illness coming on, await to further study.
(4)Other: Abnormal state that noradrenaline interacts with the myocardium receptor; Unusual fast the intersection of room and room it conducts makes interventricular septum and the intersection of ventricle and free wall in at electric excitement and machinery shrink to be incongruous, can find the patient's room room forms and wishes bunch and presents foetus' shape in period on histology; Heart collagenic tissue and abnormal state of the fibrous skeleton lead to the fact the permutation of the myocardium fiber is made up unusually, or the primary myocardium albumen is formated unusually; The small coronary artery unusually produces the cardiac muscle ischemically, lead to the fact myocardium fiber companion's unusual compensation is plump in the cardiac muscle.
(5)Multifactor function: Distributing the venereal disease example may be resulted from multifactor function, the concrete mechanism fails to understand.
|