Is the cause of disease of the plump type myocardium disease? 's general knowledge

Is the cause of disease of the plump type myocardium disease? 's general knowledge
The cause of disease of the plump type myocardium disease has not been very clear, someone thinks the nerve spine abnormal development of genetic disease, the catecholamine is produced too much, the cardiac muscle in development is unusual to the catecholamine response, someone proposes defective hypothesis of the gene, somebody proposes being unusual with the cancer gene expression of normal position, calcium is regulated and unusually had something to do. Tend to then a kind of genetic disease caused because of gene mutation which encodes the myocardium sarcomere at present.
The inherent cause of the plump type myocardium disease:HCM with family's history accounts for 50%, the family plump type myocardium disease is a kind of autosome dominant genetic disease. Confirm so far 10 100 multi-type mutation encoding albumen gene of skin festival can cause the family plump type myocardium disease. Pathogenic gene and mutation cause the structural defect, cause the cell function to damage. Sarcomere disorder plump and fiber take, increase, lead to the fact low to shrink state, cause cardiac muscle to be plump.
The catecholamine secretes increasing and nerve humorally to stimulate:HCM patient secretes and increases catecholamine, it causes the cardiac muscle to be plump that noradrenaline content increases and collagenous thread is arranged disorderlily in the cardiac muscle, and press difference and take shape in ventricles, but employ receptor to block pharmaceuticals and improve these adverse reactions and relieve symptom. So think sympathetically - the renal gland system may promote HCM to be the important factor that the phenotype expresses to excessively activate.
The gene expression of original cancer is unusual:It is one of the important factors of some cardiovascular vessel disease cell hyperplasia that the gene expression of original cancer is unusual. In a series of report at present, it is often held with the gene expression of original cancer that the cardiac muscle is plump, it is a plump important signal that happens of cardiac muscle that activation and expression of the original cancer gene are strengthened and lies between and leads the route.
Calcium is regulated unusually:Calcium is regulated unusually in the afterbirth quality of HCM patient. And collagenous thread arrange the disorder similar HCM. Can improve the heart relaxation function while resisting pharmaceuticals short of moneyly while using calcium, reduce the left room and flow out one and press difference.
Other factors:
A, C-mode hepatitis virus are infected with, it causes the myocardium cell hypertrophy to cause HCM that the C-mode hepatitis virus is infected with.
B, HLA gene have literature that report HCM associates with HLA antigenic B27, DR3, DR4, indicates HLA gene is related with the morbidity of HCM.
C, urging the cardiac muscle to proliferate the factor and increase, the cardiac muscle reflects to the catecholamine in the blood that increasing can bring about an advance in emergence of a disease.
(6)Neural endocrine factor: The neural endocrine is regulated unusually, mainly because the catecholamine is secreted and increased, or because the heart is excessively sensitive to the catecholamine, make blood pressure increase, cause the plump emergence of cardiac muscle.
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