Which does drug therapy of the plump type myocardium disease include? 's treatment

Which does drug therapy of the plump type myocardium disease include? 's treatment
Plump type myocardium disease (HCM) The main purpose of drug therapy is to improve its clinical symptom and still lack the clinical trial evidence in this respect at present. It is generally acknowledged it is that a gleam of uses medicine (such as general naphthalene Lip river, 200- 400mg/ d) that blocks pharmaceuticals ; Block pharmaceutical, can't can select calcium ion for use, resist pharmaceutical (such as the intersection of Vera and the intersection of handkerchief and meters of 200 1400 mg/ d while being short of money tolerate or have taboo, to , sulphur is tall and erect on the also available area) ,As to plump obstructing myocardium disease (HOCM) ,Calcium ion resist pharmaceutical while being short of money have, expand blood vessel, act on, may make, flow out dish obstruct, aggravate. As to HCM (especially HOCM) ,Nitric acid ester expand the vascular medicine to forbid while being other. Have ACEI which expands the function of blood vessel and clinical curative effect unsatisfactory of ARB medicine. Report third pyrrole amine (Disopyramide, 300- 600mg/ d) Can treat HOCM effectively. Careful to use reduce in front of the heart, medicine and measure of after-load, this point is different from other heart disease, especially when the heart function is not complete to appear, foreign digitalis preparation and diuretic strengthen myocardium contractile force and blood capacity reduce, can aggravate and obstruct in the ventricle, the room that has quick room rate when the heart declines is quiver, can use foreign digitalis. Use the intersection of diuresis and medicine contribute to, lighten symptom, lung of extravasated blood while being prudent, if block pharmaceuticals or calcium and resist pharmaceuticals to share with the receptor short of moneyly, then the result is better. Nitric acid ester medicine is right to lighten angina pectoris invalid, also should not use. Different from DCM, fluid infusion 1000- 2000ml of this disease can improve symptom.
It is significant for preventing from, diagnosis and treatment of HCM that the gene is sifted and examined, but want 10 genes, gt correctly; 300 kinds of sudden change are sifted and examined, it is not merely a kind of challenge technically, and is restricted by the law and ethics. Gene therapy may become a kind of promising intervention means in the future, but the research in this respect is only limited to animal's experiment at present. Discover, in inducing and expressing the transgenic mouse HCM model of the person troponin T of mutation at present, its dominance type can be reversed frankly by the sand of chlorine; In inducing and expressing the transgenic rabbit HCM model of - MHC of mutation, its dominance type can be cut down his spit of fland hard and reversed. Have already started too to the relevant research of facing the bed HCM patient.
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