Pathologic _'s general knowledge of cause of disease of the plump type myocardium disease

Pathologic _'s general knowledge of cause of disease of the plump type myocardium disease
Pathological change relies mainly on the fact that the cardiac muscle is plump, the heart weight increases. It can be seen on interventricular septum and free wall that the cardiac muscle is plump, it was very in the past person, it is often asymmetric (non- concentric) The sex is plump, namely every plump position of different degrees of ventricle wall is common with the left ventricle, the right ventricle is rare.
Pathological change relies mainly on the fact that the cardiac muscle is plump, the heart weight increases. It can be seen on interventricular septum and free wall that the cardiac muscle is plump, it was very in the past person, it is often asymmetric (non- concentric) The sex is plump, namely every plump position of different degrees of ventricle wall is common with the left ventricle, the right ventricle is rare. The interventricular septum is highly plump to stress, cause the left ventricle to flow out a persons who obstruct while shrinking in the left ventricle, called " plump type obstructing myocardium disease " ,Once called as " the special hair plump aorta one is left narrowly " ; The plump intensity of interventricular septum is relatively light, systolic phase has not caused the left room to flow out a persons who obviously obstruct, called " plump type not obstructing myocardium disease " . Skin of the previous papilla can also be plump, often shift and influence the normal valve function. When the cardiac muscle is highly plump, the left ventricle is reduced. Proportional cardiac muscle plump to make thickness of interventricular septum often and the wall thickness proportion is greater than or equal to 1.3 behind the left ventricle, minority can be up to 3. Have one variation getting plump myocardium disease, cardiac muscle of district plump to write relatively with apex of the heart. Pericardium of this type lower coronary artery normal, but ventricle coronary artery count it increases and in charge of to be narrow in the wall. See myocardium cells arrange disorderlily under the microscope, the deformity of nucleus, there are many cell branches, mitochondria increases, myocardium cells are extremely loose, the glycogenic content increases in cells, in addition, still have fibrous hyperplasia of a quality. It is disorderly to see the fibril of skin arrange too under the electric mirror. 2/3 of the patient bicuspid valve leaves increase and increase, is opposite to frontal lobe of bicuspid valve there is a fibrous spot piece that results from the reason that bicuspid valve and interventricular septum are touched and hit on the membrane wall in the left room of the place. A disease can happen in every age, but the cardiac muscle is plump the one under 40 years old is more serious than over 40 person, reason of such plump relation with age has not been bright. Until course of disease develop, myocardium fiber take, increase, ventricle wall plump to reduce, heart of narrow and small intensity lighten too, present manifestation in later period.
Pathologic physiology:
1. The left room flows out one and obstructs in systolic phase, the plump cardiac muscle makes the ventricle flow out one narrow. Not obstructing type, this kind of influence is still not obvious, the obstructing type is being more outstanding. When the ventricle shrinks, the plump interventricular septum skin is projected the ventricle, in the left ventricle, make in bicuspid valve frontal lobe and interventricular septum which flow out one to near and shift forward, cause left ventricle it flows out line to be narrow to shut off the wholly with bicuspid valve, this acts on in shrink, relatively obvious on later stage. The left ventricle gushes out in the early period of blood, flow out one and obstruct lightly, squirt heartbeat amount about 30%, other 70% are squirted while obstructing obviously, so arterial carotis wave show rise rapidly rise and propping up, become all marks upwards once again after dropping, then drop slowly. Flow out line, obstruct in systolic phase leading to the fact the left ventricle and flowing out the pressure difference during dish, flow out one and there is no pressure difference among the aorta. Some patients flow out one and can not obstruct obviously in the quiet interest, become obvious after sports.
2. The cardiac muscle of relaxation with unusually plump function is lowered, the expanding ability is bad, the obstacle of making the ventricle relaxation one full of taking place, can rise to keep in latter stage of relaxation. Relaxation issues of the intersection of heart and of stiff degree increase, the left room is expanded degree and lowered, therefore the heartbeat amount is reduced, full of increasing and oppressing the coronary artery in the ventricle wall. The phase of rapid filling is lengthened, full of speed and fulling of amount to reduce.
3. Ischemic cardiac muscle aerobic to exceed, preceded the intersection of form and arterial blood support, room coronary artery narrow in the wall because of cardiac muscle, the relaxation one is too long, it is caused that the tension increases etc. in the ventricle wall.
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