From what reason was plump type myocardium disease caused? 's general knowledge

From what reason was plump type myocardium disease caused? 's general knowledge
The cause of disease of this disease has not been bright. Think the inherent cause is the main cause of disease, its basis is inclination of having obvious family naturing that has illness coming on of a disease at present, often amalgamating deformity of other inborn cardiovascular vessels, some patients have a disease promptly when being born in, can see the hereditary genotype of HLA antigen in patient of this disease. Family's venereal disease example is transmitted in hereditary form of the autosome dominance, the pattern of the onset but the myocardium unsymmetry which does not have symptom is plump, there can also be typical obstructing symptom. The hereditary defect causes the mechanism having illness coming on to have the following imaginations: Catecholamine and sympathetic nervous system unusual, evidence its exchange for disease this companion go crazy ridge organize disease, first overbearing insulinogenic hypersecretion, hypertension, block pharmaceuticals effectively with receptor. Proportional a interventricular septum of foetus increases the thick and myocardium fiber and can not arrange neatly, have not shrunk back normally after born in. It has caused the interventricular septum and free wall of the left room rapidly that the room room has been conducted out of step and excited and shrinking. Primary collagen unusually causes the unusual fibrous support of heart, make the myocardium fiber arrange disorderlily. The myocardium albumen is formated unusually. The small coronary artery is unusual, it is ischemic to cause, fiber and compensating myocardium one's elder. Interventricular septum protruding in the intersection of apex of the heart and the intersection of bottom of heart and axial protruding Left deviation to face left sideways ' Concave left when being normal) ,Do not wait long while shrinking, cause the myocardium fiber to arrange disorderlily and somely and plumply. There is not a distributing case of the family or hereditary evidence, its pathogenesis is not so obvious
Pathological change relies mainly on the fact that the cardiac muscle is plump, the heart weight increases. It can be seen on interventricular septum and free wall that the cardiac muscle is plump, it was very in the past person, it is often asymmetric (non- concentric) The sex is plump, namely every plump position of different degrees of ventricle wall is common with the left ventricle, the right ventricle is rare. The interventricular septum is highly plump to stress, cause the left ventricle to flow out a persons who obstruct while shrinking in the left ventricle, called " plump type obstructing myocardium disease " ,Once called as " the special hair plump aorta one is left narrowly " ; The plump intensity of interventricular septum is relatively light, systolic phase has not caused the left room to flow out a persons who obviously obstruct, called " plump type not obstructing myocardium disease " . Skin of the previous papilla can also be plump, often shift and influence the normal valve function. When the cardiac muscle is highly plump, the left ventricle is reduced. Proportional cardiac muscle plump to make thickness of interventricular septum often and the wall thickness proportion is greater than or equal to 1.3 behind the left ventricle, minority can be up to 3. Have one variation getting plump myocardium disease, cardiac muscle of district plump to write relatively with apex of the heart. Pericardium of this type lower coronary artery normal, but ventricle coronary artery count it increases and in charge of to be narrow in the wall. See myocardium cells arrange disorderlily under the microscope, the deformity of nucleus, there are many cell branches, mitochondria increases, myocardium cells are extremely loose, the glycogenic content increases in cells, in addition, still have fibrous hyperplasia of a quality. It is disorderly to see the fibril of skin arrange too under the electric mirror. 2/3 of the patient bicuspid valve leaves increase and increase, is opposite to frontal lobe of bicuspid valve there is a fibrous spot piece that results from the reason that bicuspid valve and interventricular septum are touched and hit on the membrane wall in the left room of the place. A disease can happen in every age, but the cardiac muscle is plump the one under 40 years old is more serious than over 40 person, reason of such plump relation with age has not been bright. Until course of disease develop, myocardium fiber take, increase, ventricle wall plump to reduce, heart of narrow and small intensity lighten too, present manifestation in later period.
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