Lipoprotein and atherosclerosis study the intersection of progress and the intersection of _ and general knowledge

Lipoprotein and atherosclerosis study the intersection of progress and the intersection of _ and general knowledge
The heart, cerebrovascular incidence and mortality occupy the leading place in various diseases, atherosclerosis is its important pathologic foundation, so the study on As has attracted hundreds and thousands of scientists in the world. It is in extensive range that As study, the research in lipoprotein and As relation develops especially fast in recent years. This should attribute to the swift and violent development of the technology of modern molecular biology at first, especially animal, gene rotate dye,and strike gene except that,etc. technologies precises high at application at field. State lipoprotein E gene and strike and get rid of the little mouse and offer the more ideal As whole model. The the intersection of apoE and the intersection of defect and little the intersection of mouse and the intersection of blood plasma and cholesterol rise 5 times, triglyceride raises 68%. Even raise it with the ordinary feed, the aorta is deposited spontaneously in age of 3 months, been already developing into ripe As pathological change constantly in 5 months, can see the serious coronary artery to stop up in 8 months. The shape, position and evolution of pathological change are all similar to mankind, in addition the little mouse is cheap and breeding fast, having abundant science of heredity to study the background, make the application of this model becoming more extensive.
As pathological change is complicated, many kinds of cells, cell factors and receptors participate in this course, it is a difficult problem to further investigate it all the time wholly. Such as the macrophages in pathological change, someone thinks it has protective action that he engulfs and oxidizes toxic materials such as lipoprotein,etc., someone thinks because forming and necrosis of foam cells can bring about an advance in As. The intersection of apoE and the intersection of defect and with have, encode the intersection of MCSF and genetic the intersection of OP and little mouse of mutation, hybridize and beed little mouse, because MCSF can influence single nuclear and the intersection of macrophage and development, result hybridize monocyte and macrophage in the organization in the little the intersection of mouse and blood reduce, As pathological change taken place by it is only 1/7 of the little mouse of simple apoE defect, and does not develop until the fibrous proliferating phase, the ones that explain macrophages " Net" Function brings about an advance in As. Such ingenious research approach can also be used other cells, cell factors and mechanisms in As happen of receptor, and heredity, environment, endocrine, when the impact on As pathological change development, have bright prospects. After the intersection of apoA-I and the intersection of transgenosis and little mouse succeed, high density lipoprotein have independent the intersection of protective action and this theory on As receive the effective identification, and most scholars think this protective action is because HDL has strengthened the going against and having a change of luck of cholesterol, there is more study on this respect and deepen day by day in recent years. Have already found in all inferior components of HDL, pre - - LpAI, medical science are taught
It is that cholesterol accepts the body initially, in the quickest cell to breed the network and collect and put r-LpE, LpA- in order, have more greatly influence on RCT, but - LpA-I that know the tradition is later period and more slowly accepting the body. HDL is confirmed making RCT theory further improve by the body namely Model B street cleaner receptor recently, spoken highly of. Transship roles in RCT course such as albumens,etc. with cholesterol acylase, cholesterol ester of lecithin, also carried on deeper research. Some laboratories have carried on apoA-I gene therapy and made preliminary achievements on animal already. In As dangerous factor, it is still significant for lipoprotein of low density to increase, but find high triglyceride - low HDL is the likewise important dangerous factor independently. Put forward the concept of causing As lipoprotein table in recent years, refer to having synthesis of several kinds of metabolic disorder on certain hereditary foundation, including the particle small and dense LDL increases, high TG, low HDL, and insulin are resisted.
And some research points out meanings in advance notice such as lipoprotein incomplete body, apoE4 allele,etc.. It has practical value that pair of all these is prevented and cured clinically. Thought to lower the lipoprotein in the past and perhaps happens in As early and helpfully, seldom associate it with acute incident of coronary heart disease. Large-scale, prospective clinical coronary heart disease first grade or the second prevents the test from verifying a little in recent years, employ his spit of fland to lower lipoprotein medicine to make the acute incident of coronary heart disease reduce the amount of 30%- 40%. Accept unstable the intersection of As and the intersection of spot and piece it breaks to be main reason for acute incident of coronary heart disease extensively already now through study, a large number of corpse examine material, announce apt unstable spot that break fibrous the intersection of cap and thin, lipid and necrosis core that organization commit large and soft in main characteristic of piece. Should make great efforts to develop the instrument of the high-resolution in the future, can tell the steady or unstable spot piece in clinic promptly, thus make the pointed prevention measure. Foreign famous scientist prophesy in the 21st century the first half " the coronary heart disease will wither away " . Perhaps this is too optimistic, but constant with that of great research results in this field to emerge, heart, vascular disease of brain will minimize intensity to the mankind's danger finally. We are justified and promising.
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