Mechanism's _ general knowledge of morbidity of fatty liver

Mechanism's _ general knowledge of morbidity of fatty liver
The pathogenesis of morbidity mechanism fatty liver of fatty liver has not been clear yet so far, the following factors may play a role in suring.
1. The fat supersession is unusual: (1)The free fatty acid transports and enters the liver to increase; (2)The liver formates the free fatty acid or is formated triglyceride to increase by the carbohydrate; (3)Fatty acid oxidizes reducing in the liver mitochondrial b; (4)Lipoprotein of extremely low density formates and secretes reducing, transship the obstacle with triglyceride.
2. Hormone influences: Estrogen, cortisol, growth hormone, the intersection of pancreas and high the intersection of candy and plain, insulin and the intersection of insulin and kinds of growth factor,etc., may bring out fatty liver to form through changing the supersession source of energy.
3. Environmental factor: Diet, nutrition state, food pollution and hepatitis virus are infected (mainly HCV) It is relevant to wait for factor and fatty liver and erupt fat hepatitis, liver cirrhosis simultaneously.
4. Inherent cause: No matter alcohol or non- alcohol, the factor of all having certain heredity to have illness coming on. ALD is genetic genetic disease much, ethanol dehydrogenase (ADH) , cytochrome P450 2E1(CYP2E1) Or microsome ethanol oxidizes the department (MEOS) , aldehyde dehydrogenase (ALDH) Have the intersection of heredity and many attitude nature, act as, have highly actived the intersection of ADH and isoenzyme, highly actived CYP2E1, or at the low active ALDH, can cause the producing rate of acetic aldehyde to increase and the oxidizing rate fails.
5. Oxygen should surge and lipid pass, oxidize, damage: Urge oxides to increase and polyphenoils reduced oxygen should surge, can cause free radical or reactive oxygen from molecule oxygen to increase, reactive oxygen and many the intersection of price and unsaturated fatty acid get up lipid cross, oxidize, react, turn into oxidize lipid.
6. Immunoreaction: The new antigen is expressed, the lymphocyte phenotype changes, humoral antibody and cell factor relate to immunoreaction.
7. The liver is sifted and changed: The liver sinus endothelial cell layer takes the form of structure (the liver is sifted) of mesh opening ,It has the alternative to lipid supersession, it is normal in order to maintain liver structure; Liver sift structure and change of function can cause the intersection of lipid and the intersection of supersession and obstacle cause fatty liver, the intersection of liver and the intersection of fiber and take and liver cirrhosis.
8. The function of the free fatty acid: The fat oxidation phosphorylation and b of fatty acid of liver is oxidized and damaged and played a key role in forming of fat liver illness.
9. The oxygen deficiency and liver circulate the obstacle a little: Long-term serious fatty liver but because the hepatocyte that the supersession serious disorder or lipoprotein changes oppresses the liver sinus in the liver, cause the hepatocyte ischemic necrosis, thus bring out the fiber liver cirrhosis liver. It is different that process and probability of liver cirrhosis take place in alcohol and non- alcohol fatty liver, may be different from both causing the liver to circulate the obstacle and intensity which is short of oxygen a little and relevant.
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