Fatty liver sums up _'s general knowledge
Summary
Fatty liver is a kind of common clinical phenomenon, but not a kind of independent disease. The lighter of clinical manifestation of it has no symptom, the serious one condition is violent. Generally speaking, fatty liver belongs to reversible disease, diagnose in early days and treat and can often return to normal in time.Total the intersection of lipoprotein and quantity under normal liver of people, account for 5% that liver weigh, include phosphatide, triglyceride, the intersection of lipoprotein and acid, cholesterol and cholesterol lipoprotein. And person of fatty liver suffered from, total the intersection of lipoprotein and quantity can up to 40%-50%, triglyceride and lipoprotein sour mainly, and phosphatide, cholesterol and cholesterol lipoprotein increase only on a small quantity.Enter the special topic of fatty liver
Cause of disease
The morbidity of fatty liver relates to the following six factors:
The intensity that the fat piles up is proportional to weight in the fat liver, about half the a fat patient can see slight fatty liver, in the patient of the severe obesity, the morbidity of fatty liver can be up to 6,000 points - 9,000 points, can be seen the fat patient and have obvious fatty liver to send inclination well. After bulk's weight is controlled, its fatty infiltration also reduces or disappears. Suffer from behind the hepatitis increasing nutrition and it lacks due to sport fat to be the intersection of our country and causing reasoning of fatty liver most common inappropriate.
Alcohol, according to puncture, examine while being alive to long-term the intersection of wine-head and liver, 7,500 - 9,500 there is fatty infiltration. Studies have suggested, the result relation of the having amount among the consumption of alcohol and incidence of fatty liver, then incidence of the ethanol fatty liver increase by 5-25 times to drink over 80-160 grams every day. The multifactor and comprehensive result at present of the mechanism that it has illness coming on, a large number of ethanol can inhibit the formation of the mitochondrial albumen in the body at first, the ability of making mitochondria oxidize the fat is reduced, cause the liver to organize fatty acid to pile up, acetone body pile up in body, internal lactic acid, third the intersection of ketoacid and ratio increase, lactic acid too much to inhibit urine from to be sour to discharge by the kidney, cause high urine acidaemia, make the opposite sex of the glycogen of liver reduce, cause the hypoglycemia, some patients die suddenly. In addition the intersection of supersession and product such as acetic aldehyde of ethanol organize itself to have toxic function directly to the liver, cause the liver to organize the fat to change the sex.
It is the important reason for causing fatty liver like adding the west card disease that protein - insufficient malnutrition of heat lacks protein, it see more it is insufficient since it ingest or by obstacle,can't lipoprotein of years synthetic,so that pile up at liver triglyceride, form fatty liver. The free fatty acid of serum increases at the time of the hunger, can cause fatty liver to take shape, its mechanism may obtain lacking, growth hormone and increase and have something to do with the excitative increase of sympathetic nerve with glucose, the intensity that and the liver fat changes the sex depends on the size of hungry time. Empty the intersection of ileum and records of the intersection of way and skill and stomach cut apart postoperative, internal fat mobilize and increase, can also lead to the fact fatty liver.
Diabetic the intersection of diabetic and average 5,000 can take place fatty liver, 40- 50 year old take place glycosuria apt to appear patient the fat is deposited in the liver very. It have illness coming on mechanism know, may increase with the intersection of patient and the intersection of blood plasma and insulinogenic competence very much still at present, esterified fatty acid density rises and has something to do in the blood plasma.
According to statistics, 200 more than more than types of medicines can cause fatty liver at various degrees at least in the medicine, such as tetracycline, rifampin, isonicotinyl hydrazine, adrenocortical hormone, purine are mould to usually surround amine emetine and antibiotic, central nervous system function medicine, testis ketone hormone etc.. The statistics show, the incidence of medicine fatty liver occupies the third place in all medicine bad reaction cases. Relatively complicated mechanism its, until tetracycline can combine on the RNA to reach the hepatocyte damaging the synthetic function of the hepatocyte, make the previous albumen, lipoprotein of extremely low density, three acyl glycerine of lipoprotein of extremely low density formate and reduce, the obstacle happens and fatty liver happens in the function that oxidation and hepatocyte of an internal fatty acid of line absorb fatty acid.
Poisonous substance common fatty liver and poisonous substance are tetrachloromethane, yellow phosphorus, different propanol, ring own amine, emetine, arsenic, lead, mercury,etc.. It have illness coming on mechanism to be comparatively complicated, tetrachloromethane albumen formate in the liver through inhibit from for instance, reduce the fatty acid oxidation rate in the liver, it causes fatty liver to take shape to make triglyceride of liver release the obstacle. And the yellow phosphorus mainly causes inner protein of liver, lipoprotein formates the obstacle and making lipid is secreted and reduced in year, the fat piles up in the liver and causes fatty liver to take shape. Different propanol can make 2 - glycerophosphate in the liver increase, the fat cell decomposes the fat and increases, esterified fatty acid enters liver to increase too, make three acyl glycerine in liver formate too much, form fatty liver.
Symptom
Light fatty liver can have any symptom, or CT check etc. find through B -type supersound only. After fatty liver takes shape, or secret anguish that the majority displays losing the appetite, disgusting, vomiting, weight and drops, weak, uncomfortable in abdominal distension, liver district, third amino acid transaminase (ALT) Raise, a few patients can present slight jaundice. The physical examination can touch the swelling liver (generally within 2-3 centimetres under right rib) ,The surface is smooth, the edge is round and blunt, the soft or medium-sized hardness of the texture, there can be slight tenderness, some patients knock and hit aching. The serious disease patient can present liver cirrhosis and behave.
Check
Check in the laboratory: Liver function ALT is normal or rises, there is high lipoprotein blood disease that behaves, triglyceride rises, serum - GT rises actively, electric swimming blood plasma globulin of albumen increases.
Supersound and CT. The B -type supersound reveals the liver increases, the essence presents the dense strong reflection luminous point, the deep department organizes the echo to decay. CT scans and reveals the liver density than other essence internal organs (such as the spleen) Low.
The liver is examined vivid. Confirm the basis.
Treat
It is to remove the cause of disease to treat the principle, adjust the diet, increase sports, use medicine rationally.
1. Remove the cause of disease. Remove all factors that can cause fatty liver. Stop drinking and employ the high protein diet, can often reduce the fat in the liver effectively. Alcohol fatty liver to stop drinking mainly, pay sufficient protein diet, make the fat piled up in the liver remove effectively; The overweight person wants to reduce weight; The diabetic patient should treat to have illness coming on originally.
2. Adjust the diet. This treats an important link of fatty liver. The diet needs high protein, right amount of fat and candy
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