New treatment _'s treatment of fatty liver

New treatment _'s treatment of fatty liver
In recent years, crowd's quantity of fatty liver that various reasons such as fat, diabetes, high ester blood disease, get drunk cause is increasing constantly, and become first, the second cause of disease of chronic hepatopathy of developed country and developing country gradually. International the intersection of hepatopathy and authority's academic magazine of research field " the liver disease is studied " ' >) Published the latest find that our country cooperates with American physician this month, this is a thesis of the relation among first report fat hepatitis and regulating T cell of this research field.
Shanghai channel of www.xinhuanet.com: Simple fatty liver is generally comparatively steady, but once change into fat hepatitis, the probability of liver fiber, liver cirrhosis happens to increase greatly. A China and the United States scientist's latest cooperation finding: In this transition, a kind of immune cell called regulating T cell may play an essential role.
If offer certain antioxidant before the liver should defy by oxygen, then regulating T cells wither and die and reduce, and can lighten inflammation in fatty liver in the liver. Ma Xiong says: Regulating T cells may block simple fatty liver to change into the last of fat hepatitis " The line of defence ".
One of the persons in charge of the subject, Shanghai digests the Deputy Director of research institute of disease, fat hepatopathy in Shanghai and treats the Deputy Director of research center, horse's male associate professor of gi medicine of Yan Chai Hospital and introduces, on clinic, divide non- alcohol fat hepatopathy into simple fatty liver, fat hepatitis and fat hepatitis and relevant liver cirrhosis. Simple fatty liver is relatively stable, 10-20% among them will develop for fat hepatitis, have in the fat hepatitis patient liver fiber, liver cirrhosis will happen in 25-35%. Once scholars prophesied, fat hepatitis would become the main cause of disease with depleted liver function between future 20 and 30. So, OK implement while simple fatty liver develops for fat hepatitis " Intercept and " already become the research focus of clinical medicine on the way.
It has not been totally expounded yet for the mechanism of fat hepatitis that simple fatty liver develops, including oxygen should be surged and many kinds of factors such as the disorder of immune adjustment in liver are thought to relate to this course. Regulating T cells (CD4 +CD25 +Foxp3 + T cells) Participate in the immune adjustment of liver. The research group which Ma Xiong headed and Sri Lankan of American John Hopkin (Johns Hopkins) Li Zhi, flat doctor of university medical college is representatives' cooperation of research group, have observed the function that regulating T cells play while fat hepatitis have illness coming on especially.
Discover, through the little mouse which show fatty liver will happen 8 weeks later in the diet of high lipoprotein, about 1/2 that regulating T cell quantity drops to the little mouse of normal diet in liver. Scientific research personnel's first discovery, regulating T cells will seem to go through oxygen which oxidizes simulation of hydrogen outside the body when should surge the state ing " In delicate health ", wither and die the index obviously rises. Study, find, lead to the fact the reason of phenomenon might T of regulating etc. one resist, wither, die genetic Bcl-2 express competence to be lower inside the cell further. On the contrary, if offer certain antioxidant before the liver should defy by oxygen, then regulating T cells wither and die and reduce, and can lighten inflammation in fatty liver in the liver.
Ma Xiong says: Regulating T cells may block simple fatty liver to change into the last of fat hepatitis " The line of defence ". The characteristic will probably develop into the new route to treat fat hepatitis to adjust and control the quantity of regulating T cells in the liver, or adjust and control cells to wither and die.
It is reported, the series about the non- alcohol fat hepatopathy are studied, already got the subsidy of our country's national natural fund project continuously since 2006, this discovery is exactly an item of main research results among them. How person who adjust through adjustment the intersection of T and cell wither, die characteristic raise cell, resist, wither ability of dying, raise the intersection of fatty liver and subject for research of therapeutic effect further, the national natural fund project will be started as 2008 soon.
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