The therapeutic research of fatty liver makes the _ treatment of the break-through
American John. Hopkin university of Sri Lankan discovers, to the experiment mouse at least, a the intersection of help and diabetic control medicine - two the intersection of first and guanidine of insulin may suitable for, treat fatty liver - one diabetic, occur frequently disease too. But the diabetic expert claims whether two first pair guanidine has the same curative effect to the mankind, can't fix yet at present. Have not told it to stop hormone that is eaten in mouse's body of experiment trained in the laboratory specially, but has this kind of hormone in the human body.
This university Anna Mae Diehl professor thinks, this discovery is of great significance. The diabetic will result in losing one's sight or renal failure, but have illness coming on early symptom is not obvious, the doctor wants to check and find. But fatty liver is different. People offer the attention to fatty liver recently, and the doctor does not usually do the inspection. Do not know whether two first pair guanidine is effective in cure to the mankind now. But animal's model is very similar, so this result is very important.
Diehl and colleagues have taken two first pair guanidine for 4 weeks in succession for the experiment mouse which suffered from diabetes, in order to make them fat, researchers have all revised the gene of mouse of these experiments. Two first pair guanidine is used by doctor's prescription, make the diabetic more sensitive to insulin, in this way they can use insulin that one's own health produced. Fatty liver that tested the mouse finally disappeared, the liver resumed normal size.
American diabetic association's president Robert Sherwin thinks, experiment mouse and the mankind that the gene revises have essential distinction. He point out experimental subjects human the intersection of model and different the intersection of first and particular animal model. "These experiment mouse lack one call, rein in the intersection of handkerchief and the intersection of eggplant and hormone of alkali, talk with brain and shut off to enable the experimental mouse fat taking food the behavior while reining in eggplant alkali of Pablo. The human fat does not exist and rein in the defective problem of eggplant alkali of the handkerchief, tying eggplant alkali of the handkerchief tight will have other metabolism functions to the liver, function on how it will be the intersection of animal and model and medicine in human body mechanism related and clear at present. So, two first pair guanidine treats the result of fatty liver to also need verifying under clinical environment.
Diehl says that thinks fatty liver relates with II -type diabetes. Fatty liver in diabetes has not been paying enough attention all the time, because it has very long natural development history, usually decades belong to clinical disease once. So will not find its existence unless observe closely for a long time. It is estimated, there are Model 16 millionII diabetics in U.S.A., the glucose level is improved in patient's blood vessel. Presenting this kind of situation sometimes, because the health is unable to make enough Langerhans' islits, insulin is used for dealing with glucose and and help it to enter hormone in cells. At other time, cells just stopped being responsible to insulin.
Fatty liver is permeated through the hepatocyte by the fat to cause, often relate to insulin. The infection that leads to the fact can cause pain or form scar, namely liver cirrhosis appears. There is fat that is deposited in liver of the adults of about 1/4 of a lot of developing countries. Liver cirrhosis is incurable disease, can cause the death finally. The doctor proposes the only treatment used for treating fatty liver is to reduce weight and do exercises, because there is not any medicine to treat fatty liver effectively at present.
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