Friday, March 15, 2013

Fatty liver causes unusual _'s general knowledge of liver function

Fatty liver causes unusual _'s general knowledge of liver function
It is unusual that the fatty liver patient can present one or many liver function tests. Adult's health physical examination unusually person finds liver function, about 35% are the fatty liver, so, have symptom (old to spend SGPT) ALT The most common reason is fatty liver to rise, instead of virus hepatitis. Liver function unusually looks at the intensity, range and disease of fatty infiltration in liver therefore make. Can Zhyuan offer to bungle striking # slightly The intersection of fonticuli cranii and flesh, brother of , pass on and LT AST (old to spend SGOT) To intermediate to rise (exceed normal 2 of value generally slightly- 3 times) ,Non- alcohol fatty liver appear the intersection of AST/ALT and ratio smaller than I often, and alcohol lipoprotein liver AST/ALT ratio greater than 2 often. GGT can also raise, alcohol rise particularly obvious at the fatty liver, about 30% serious the intersection of fatty liver and patient can appear ALP at various degrees rise. About over half fatty liver patients present the dyestuffs (indigo and dark green) Excrete and test unusually. Serum bilirubin, albumin, PT do not usually have obvious change. The chronic serious disease fatty liver patient can also present the total amount of plasma protein and change to invert with the albumin globulin proportion sometimes, PT lengthens, employing vitamin k can be corrected. But live and examine fatty liver verified by the liver, only 20%~30% of the patients have one or several above-mentioned unusual indexes, so can not check precise existence and intensity which reflect fatty liver in the laboratory.
What pathology changes there is fatty liver?
Fatty liver is that a kind of common liver pathology changes, it is the manifestation in early days that various liver toxicity damage. Great the intersection of bodily form and attitude, histology and inferior micro-structure of liver a series of change takes place at the fatty liver.
(1)The great bodily form attitude changes: Liver appearance present person who fill the air to be swelling, edge blunt thick, surface smooth, quality if dough, can appear dent at the oppression, surface pale color and luster bring getting grayish yellow, the tangent plane is yellow and red or faint yellow, there are greasy senses. When the knife is cut, the hardness increases slightly than the normal one, each has fat and is infected with.
(2)The optical microscope is observed: The hepatocyte is swelling, full of fat vacuole (lipoprotein is dripped) not of uniform size ,Vacuole large can push the nucleus of liver to by the large oning. Several hepatocytes which contain the fat can break, form fat cyst, cyst can cause inflammation to react after breaking. It is most obvious that light to change the sex in the small leaf centre district of liver to the intermediate fat, do not generally have obvious inflammation reacting and cell necrosis. The hepatocyte of the small leaf of severe patient's whole liver has fat to change the sex, with slight limitation inflammation and simple necrosis. Middle, severe fatty liver can be with the fibrous hyperplasia of connective tissue (liver fiber) of liver of a certain degree ,Accompany hepatocyte regeneration. Fat oppression, when the maos of detailed bile duct, it is obvious the bile is deposited in the hepatocyte. After treating effectively, the fat is reduced in hepatocyte or cyst, the hepatocyte can return to normal. If original inflammation or fiber, can still leave over the office cooking stove inflammatory cell soaking and fiber in short term after the fat disappear.
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