's general knowledge of development of toxic concept of the lipoprotein

's general knowledge of development of toxic concept of the lipoprotein
American scholar's storehouse is inferior (Cusi) Point out, it means long-term energy supplies needing over the supersession that lipoprotein toxicity is damaged, lipid supersession route has been changed and entered harmful oxidizing the supersession route, result in promoting inflammation and toxic supersession product that withers to die to assemble in a large amount. Lipoprotein toxicity mainly influences the liver, skeleton skin and Langerhans' islits 's cell, these organs have function which keep the normal internal environment energy steady state. In term of this meaning, lipoprotein toxicity helps us to understand the morbidity course of fat hepatitis, carry on the liver when regulating and behave to the surplus energy of whole body.
While suffering from fat, 2 type diabetes and NAFLD, the excessive lipoprotein of triglyceride solves and free fatty acid (FFA) Production last core on lipoprotein is toxic for IR. In the fat NASH patient, nearly 2/3 of the liver fat and lipoprotein cholesterol of extremely low density of blood plasma come from endogeny FFA.
It is reversible that the lipoprotein toxicity of the liver, muscle, Langerhans' islits 's cell is damaged and passed to intervene. The method to intervene is as follows, the intervention of the of intervention of diet and life style may make the fat of the hepatocyte change the sex and improve rapidly, react with fiber it takes relevant data of benefit to be very limitedding to necrosis inflammation, and most relevant research is a short time, little sample one, the evaluation index is only third amino acid amino transferase (ALT) Learn and display etc. with the image, but not pathology behaves. The weight-reducing operation is effective to the fat individual of the morbid state. The medicine is intervened Treat in NASH patient in a short time (6~12 months) Research in find thiazole alkane two ketones medicines (TZD) Verify into most effective medicine at present, can prevent because to the intersection of and damage of cell 2 type diabetes the intersection of lipoprotein and toxicity. But long-term therapeutic research is in process.
Can know to have, the extensive supersession that lipoprotein toxicity causes will involve different tissues of whole body to damage, the liver is not it causes the only isolated injured organ damaged that it is piled up that lipid is excessive. As the supply of lipid has exceeded the range that supersession ability compensates, being similar to cells should defy the damage reflected to happen on different organs: Lipid passes oxidizing, mitochondrial function disorder, change, forming, activation of protein kinase, activation of inflammatory route of inner quality network ROS of lysosome cell membrane. It is determined that the supersession regulates successes and failures (namely chronic inflammation and fiber) Factor clear totally yet, be must study further at foundation and fields clinicalled. The organ of the impact on lipoprotein toxicity may contribute to monitoring and management of fat, MS, NAFLD, 2 type diabetic while carrying on overall and prospective investigation and assessment.
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