Kind of insulin

Kind of insulin
On the basis of the source of insulin, can divide two big classes, namely animal insulin and people insulin. Insulin of animal: Mainly have pig insulin and insulin of ox. Insulin of animal is mainly from the animal (pig or ox) Pancreas draw to last purification,because of as insulin that be produced by oneself humanly at various degrees difference in structure, therefore after injecting and entering the human body, the human body one " The system of defence " Namely the rejection (call immunoreaction on medical science) will take place in the refered immune system on medical science ,Produce one to call " The antibody " Material, lasting insulin that is internal to combine,be caused insulin not to can't last efficiency to lower blood glucose, cause some patients, insulin injected can't give play to and lower the efficiency of blood glucose, the insulinogenic dosage injected will be larger and larger, cause insulin to fail gradually as time passes, a few patient immunoreaction is relatively serious, can present rash, generate heat, itch all over, even blood pressure drops, shock,etc., these patients can't continue treating with this kind of insulin. Because animal insulin exist the above insufficient, at present already gradually a new kind of insulin - the intersection of people and insulin(artificial genetic engineering formate the intersection of people and insulin) Replacement. People insulin: Does not draw in the human body, but it is synthetic to rely on the advanced Hi-Tech production technology of artificial gene, its insulin of structure, function and people is similar, the main production method is as follows, *the chemical disposal of paying insulin of animal, and make it change adult insulin. *Recombinant DNA technology: It is a kind of chemical course that can formate insulin unrestrictedly. In particular, the bacterium (Escherichia coli) of a kind of special type trained in the laboratory ,And join the passage with people's insulinogenic gene in this kind of Escherichia coli, through a series of chemical course of duplicating, fermenting etc., formate people insulin finally. This is a method of insulin of most frequently used synthetic people at present. Insulinogenic specification: In order to meet the needs of difference of different patients, develop insulin of a lot of different specifications and produce in a large amount, the differentiation method of insulin of different specifications mainly depends on time of function: *Get up for time of result: Insulin injects the late arrival and enters blood to produce and lower the time on function of candy. *The time of peak value: Insulin acts on * function of strongest time and maintains time: Insulin act on, begin, disappear time by the intersection of late arrival and function. There is obvious mark of the insulinogenic specification on the label of the insulinogenic bottle, for instance: R =Regular Langerhans' islits plain S =Half slow Langerhans' islits plain N =NPH insulin, namely precise protein insulin of neutral fish L =Langerhans' islits plain U of slow result =Specially slow Langerhans' islits plain 50R 50/50 =50% NPH insulin and mixed solution of 50% of the regular insulin. 70R 70/30 =70% NPH insulin and mixed solution of 30% of the regular insulin. It is fugitive insulin all with half slow insulin to be regular, result of getting up, fast, and function time shorter. NPH and slow result all the intersection of result and insulin in being in insulin, the insulin play result time, peak value and function time long than fugitive insulin all. Specially slow insulin is a kind of long-efficiency insulin, its time of function is longer, but there is no peak value to appear. PZI, namely the precise protein of fish zinc insulin, it is a kind of long-efficiency insulin. 50/50,70/30, all in order to mix insulin, it is mixture which hits insulin of result and fugitive insulin, therefore does not need patients to mix before the injection by oneself.

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