The diagnosis of the pancreas with main cancer explains _'s general knowledge

The diagnosis of the pancreas with main cancer explains _'s general knowledge
Biochemistry, zymology and immunity are determined commonly used biochemistry is checked, for instance serum bilirubin and liver enzyme (A K P,etc.) ,See that rises while only obstructing in the biliary tract, lack the specificity too, is not suitable for the diagnosis in early days of pancreas cancer. What value the change of the amylase of serum does not have to chronic pancreatitis and diagnosis of pancreas cancer. No matter from duodenum drainage tube or E R C P (the driving in the wrong direction pancreatic duct radiography of gallbladder of the endoscope of the foot-path) Guide 12 made, mean the intestinal juice, check, pancreas is 14% alone of positive rate of tumour cell, this a pancreatic duct obstructs and prevents cells from falling into 12 causes of pointing in the intestinal juice.
1. The milk ferritin in the pure pancreatic juice that the ferritin of milk obtains with the endoscope radiates the immunity to determine, with 125I mark milk ferritin, antiserum has been made since people separate the immune sheep of pure milk ferritin that obtains in milk, the sensitivity is very high. Its average of the normal pancreas person is 83 gL, pancreas cancer and chronic pancreatitis person are 105 g/L and 2240 g/L respectively, method continuing being tried to find out that this is a worth.
2 . Embryo antigen of cancer (C E A) 8 0 - 9 0 % C E A value of pancreas cancer exceeds 2. 5 n g/m l, but it lack specificity, in primary or the intersection of colon and rectal cancer and other to digest department's tumour, meet even that increase of shifting etc., if C E A value exceeds 10 n g/ml, Ultrasonography B, C T or endoscope examine, find the pancreas unusual at the same time, then possibility increase of pancreas cancer.
3 . Relevant antigen (P C A A) of pancreas cancer Its value increases as the condition of pancreas cancer is developed, there are higher specificities, can be regarded as the cause of disease that further study pancreas cancer, organized pathology grading and sign of the metastasis of cancer in early days.
4 . Tumour fetus antigen of pancreas (P O A) Mainly exist in foetus' pancreas and adult's pancreas cancer are organized, there are traces in the adult's colon and small intestine extract. Determine patient serum hits P OA density by quantitative electric swimming method of rocket immunity, the normal value is 0-4 units of %, 4 0 - 6 0 % P O A value of pancreas cancer can exceed 14 units of %. Like C E A, its clinical using value lacks the specificity too.
5 . Galactose glucoside shifts isoenzyme 2 (G T - 2) It is an enzyme in the glycoprotein biosynthesis, can be seen on 7 0 - 8 5 % In gastrointestinal cancerous swelling, sensitiveness is too bad, can't be used for screening.
6 . Ribose nuclease gathers widowed nucleotide transferase of of nucleoside, is abbreviated as ribose nuclease (R N a se) ,Can be divided into pancreas type and liver spleen type according to its source of tissue, is abbreviated as R N a seC and R N a seU respectively, its substrate each has specificity. The experiment proves, R N a seC content in the pancreas and blood is higher than other histoorgans more than 100 times, and R N a seC in serum mainly comes from the pancreas and organizes. R e d di should be used to gather the nucleotide of cytosine (P oly C) at first in 1976 Determine, the critical value of normal people is 250 ml, the pancreas cancer patient of 90 is higher than 250 ml for enzyme law of the substrate, but the other cancerous swelling cases of 90 are lower than this value. In diagnosis, pancreas of cancer, ribose nuclease determine law evoke clinical attention of worker already with sensitiveness and specificity of 90 of 90 their, worth further studying.
7 . Other serology developed recently mark thing C A 199, D U P A N 2,etc.s, the patient can find C A 19-9 or D U - P A N 2 of the high density with monoclonal antibody in 90's pancreas, but if tumour is smaller than 3 c m, sensitiveness is 57; , his number value is normal at the time of the pancreas cancer that can excise at 2 stage; Diagnose value very high in its number value, it is mostly pathological changes not excised to cherish. Elastic hard protease of immune reactivity of serum can see rising when pancreas cancerous swelling blocks the proximal pancreatic duct, tumour is dropped to the normal range after excising, so recur to monitoring usefully.

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