Embryo's stem cell has soft gel ground substances of new law to replace to train hard and train wares

Embryo's stem cell has soft gel ground substances of new law to replace to train hard and train wares
According to daily December 19 of scientific net of U.S.A., American researchers find, utilize soft gel ground substance to replace hard to train wares to train the little mouse embryo's stem cell, do not need to add expensive growth factor, can let the stem cell train things to maintain the multi-functional state of homogeneity for a long time. Researchers say, this technology has enormous application prospect in future regeneration medical science. It is here that the relevant thesis is issued >On the magazine .
The main obstacle faced in stem-cell research is how to let the little mouse embryo's stem cell train things to keep a kind of homogeneous multi-functional state. The multi-functional stem cell can divide into different tissue types such as skin or muscles spontaneously, for a long time, many energy states that the scientist makes use of a chemical material called growth factor to maintain the stem cell do not change, but even so, the stem cell that trains out will enter their own division stages quickly, appear different gene expression and shape, such diversified division make stem cell train thing to be very difficult to induce into particular organization required to turn into.
One of the persons in charge of this research, biological animal scientific professor Tian ZhongZhe of research institute of genome of University of Illinois express too, can start with training the not division cells of a group of homogeneity, lure it into dividing it into particular cell type in order to realize clinical practice.
The research group finds, it be small mouse's embryo's stem cell likes " L Unite " R Stick it together, and is in the edge of colony, cell contacted with the hard cultivation ware to differentiate relatively fast, then they decide to carry on mechanics research but not chemical research to the little mouse embryo's stem cell. Because the stem cell is 10 times softer than ripe cells, researchers guess whether to train the mechanical force between ware and cell to stimulate cells to split up, and it verifies, the inducible cells of even very small mechanical force split up to study through earlier stage.
Connect, the research group divides the little mouse embryo's stem cell into 3 groups and carries on parallel test: The first group is trained with regular culture medium which has added growth factor; The second group adopts the soft gel ground substance of the hardness to train as these cells, and put into growth factor; The third group is trained with the soft gel ground substance too, the factor that but not joined to grow. The result reveals, even lack growth factor, spend the stem cell that the soft gel ground substance trains can still demonstrate more obvious homogeneity and multi-functional after going down to posterity 20 times more than 3 monthsing.
The intersection of research and cooperator, University of Illinois mechanical science and Wang Ning, Professor of engineering department ' Transliteration) Say, this has reflected dual character of the things: Mechanical force can be induced and split up, but if reduce the mechanical force between culture medium and stem cell, can keep the stem cell in the multi-functional state. This research has verified the importance of the mechanics environment is not second to chemical growth factor while the stem cell splits up. In living organism, cell the factor grows in the short-term endocrine only, but mechanical force is influencing each cell all the time.
The research group plans to make use of this kind of new technology to train and induce the multi-functional stem cell (iPS) next ,Though iPS cell medical science employs and has a bright future, it is famous and difficult by cultivation too. Tian ZhongZhe says too : " We can try to train little mouse iPS cells on the soft ground substance equally, see the stem cell that can obtain homogeneity too trains things. If the situation is really like this, its influence produced will be undoubtedly enormous. " (Chen Dan)
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